γ-Secretase Inhibitor XXI
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- $160 - $1900
- Product name: γ-Secretase Inhibitor XXI
- CAS: 209986-17-4
- MF: C27H24F2N4O3
- MW: 490.5
- EINECS:-0
- MDL Number:
- Synonyms:N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide;CoMpound E (secretase inhibitor);DuPont E;g-Secretase Inhibitor XXI;γ-Secretase Inhibitor BZ;γ-Secretase Inhibitor XXI;(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S,Z)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide;(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide
21 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Alfa Aesar
- Ambeed
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- CSNpharm
- Sigma-Aldrich
Package
- 250μg
- 0.5mg
- 500μg
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0081-M001
- Product descriptionCompound E ≥98%(HPLC)
- Packaging1mg
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number6731CS
- Product descriptiongamma-SecretaseInhibitorXXI
- Packaging5mg
- Price$725
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ65131
- Product descriptionCompound E
- Packaging0.5mg
- Price$307
- Updated2023-06-20
- Buy
- ManufacturerAmbeed
- Product numberA1145654
- Product descriptionCompound E 98%
- Packaging5mg
- Price$553
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1487
- Product descriptionγ-SecretaseInhibitorBZ-CompoundE 99%
- Packaging5mg
- Price$236.5
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD103782
- Product descriptionCompound E (secretase inhibitor)
- Packaging1mg
- Price$170
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD103782
- Product descriptionCompound E (secretase inhibitor)
- Packaging2mg
- Price$320
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD103782
- Product descriptionCompound E (secretase inhibitor)
- Packaging5mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD103782
- Product descriptionCompound E (secretase inhibitor)
- Packaging10mg
- Price$800
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD103782
- Product descriptionCompound E (secretase inhibitor)
- Packaging25mg
- Price$1000
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15579
- Product descriptionCompound E ≥98%
- Packaging500μg
- Price$189
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15579
- Product descriptionCompound E ≥98%
- Packaging1mg
- Price$322
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0003250
- Product descriptionCompound E 99.87%
- Packaging1mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0003250
- Product descriptionCompound E 99.87%
- Packaging5mg
- Price$520
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0003250
- Product descriptionCompound E 99.87%
- Packaging10mg
- Price$920
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0003250
- Product descriptionCompound E 99.87%
- Packaging25mg
- Price$1900
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-0081-M001 | Compound E ≥98%(HPLC) | 1mg | $190 | 2021-12-16 | Buy |
| AK Scientific | 6731CS | gamma-SecretaseInhibitorXXI | 5mg | $725 | 2021-12-16 | Buy |
| Alfa Aesar | J65131 | Compound E | 0.5mg | $307 | 2023-06-20 | Buy |
| Ambeed | A1145654 | Compound E 98% | 5mg | $553 | 2021-12-16 | Buy |
| Axon Medchem | Axon1487 | γ-SecretaseInhibitorBZ-CompoundE 99% | 5mg | $236.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD103782 | Compound E (secretase inhibitor) | 1mg | $170 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD103782 | Compound E (secretase inhibitor) | 2mg | $320 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD103782 | Compound E (secretase inhibitor) | 5mg | $500 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD103782 | Compound E (secretase inhibitor) | 10mg | $800 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD103782 | Compound E (secretase inhibitor) | 25mg | $1000 | 2021-12-16 | Buy |
| Cayman Chemical | 15579 | Compound E ≥98% | 500μg | $189 | 2024-03-01 | Buy |
| Cayman Chemical | 15579 | Compound E ≥98% | 1mg | $322 | 2024-03-01 | Buy |
| ChemScene | CS-0003250 | Compound E 99.87% | 1mg | $160 | 2021-12-16 | Buy |
| ChemScene | CS-0003250 | Compound E 99.87% | 5mg | $520 | 2021-12-16 | Buy |
| ChemScene | CS-0003250 | Compound E 99.87% | 10mg | $920 | 2021-12-16 | Buy |
| ChemScene | CS-0003250 | Compound E 99.87% | 25mg | $1900 | 2021-12-16 | Buy |
Properties
Boiling point :778.6±60.0 °C(Predicted)
Density :1.31
storage temp. := -70C
solubility :Soluble in DMSO
form :Liquid
pka :12.54±0.40(Predicted)
color :White to off-white
Sensitive :Light Sensitive
Density :1.31
storage temp. := -70C
solubility :Soluble in DMSO
form :Liquid
pka :12.54±0.40(Predicted)
color :White to off-white
Sensitive :Light Sensitive
Safety Information
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Description
γ-Secretase is a multimeric aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. Two well-known substrates are the carboxyl-terminal fragments (CTFs) of the receptor Notch, which has key roles in development, and that of amyloid precursor protein (APP), which is important in Alzheimer’s disease. Compound E is a potent, cell-permeable, and selective inhibitor of γ-secretase, blocking the cleavage of both APP and Notch CTFs with IC50 values of ~0.3 nM. Compound E induces neuronal differentiation, impairs ovarian folliculogenesis, and suppresses thymocyte development by preventing Notch activation by γ-secretase.Related product price
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