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ChemicalBook >> CAS DataBase List >> GAMBOGIC ACID

GAMBOGIC ACID

GAMBOGIC ACID price.
  • $33 - $4151
  • Product name: GAMBOGIC ACID
  • CAS: 2752-65-0
  • MF: C38H44O8
  • MW: 628.75
  • EINECS:
  • MDL Number:MFCD16878985
  • Synonyms:GaMbogic aci;BETA-GUTTIFERIN;BETA-GUTTILACTONE;GAMBOGIC ACID;GUTTATIC ACID;β-Guttilactone;2-Butenoic acid, 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, (2Z)-;1,5-Methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonic acid
Price39 Properties Safety Information Description
39 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • BroadPharm
  • Cayman Chemical
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10MG
  • 20mg
  • 25mg
  • 10
  • 50
  • 100mg
  • 250mg
  • 10mM(in 1mL DMSO)
  • 50mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberX1145
  • Product descriptionGambogic acid
  • Packaging50mg
  • Price$375
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX1145
  • Product descriptionGambogic acid
  • Packaging100mg
  • Price$742
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200522
  • Product descriptionGambogic acid ≥97%(HPLC)
  • Packaging50mg
  • Price$82
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200522
  • Product descriptionGambogic acid ≥97%(HPLC)
  • Packaging100mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200522
  • Product descriptionGambogic acid ≥97%(HPLC)
  • Packaging250mg
  • Price$189
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPXT0004738
  • Product descriptionGAMBOGIC ACID 95.00%
  • Packaging10MG
  • Price$648.83
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3424
  • Product descriptionGambogic acid
  • Packaging10mM(in 1mL DMSO)
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN90172
  • Product descriptionGambogic acid ≥98%
  • Packaging20mg
  • Price$118
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberSY074643
  • Product descriptionGambogic acid ≥95%
  • Packaging10mg
  • Price$182.73
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS054326
  • Product descriptionGambogic acid ≥98%
  • Packaging100mg
  • Price$364
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2366
  • Product descriptionGambogic acid
  • Packaging5mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2366
  • Product descriptionGambogic acid
  • Packaging25mg
  • Price$145
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2366
  • Product descriptionGambogic acid
  • Packaging100mg
  • Price$385
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2366
  • Product descriptionGambogic acid
  • Packaging250mg
  • Price$685
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2366
  • Product descriptionGambogic acid
  • Packaging1g
  • Price$1485
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546016
  • Product descriptionGambogic acid >98%
  • Packaging5mg
  • Price$173.4
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X1145 Gambogic acid 50mg $375 2021-12-16 Buy
AK Scientific X1145 Gambogic acid 100mg $742 2021-12-16 Buy
Ambeed A200522 Gambogic acid ≥97%(HPLC) 50mg $82 2021-12-16 Buy
Ambeed A200522 Gambogic acid ≥97%(HPLC) 100mg $125 2021-12-16 Buy
Ambeed A200522 Gambogic acid ≥97%(HPLC) 250mg $189 2021-12-16 Buy
American Custom Chemicals Corporation PXT0004738 GAMBOGIC ACID 95.00% 10MG $648.83 2021-12-16 Buy
ApexBio Technology A3424 Gambogic acid 10mM(in 1mL DMSO) $90 2021-12-16 Buy
Arctom CFN90172 Gambogic acid ≥98% 20mg $118 2021-12-16 Buy
Arctom SY074643 Gambogic acid ≥95% 10mg $182.73 2021-12-16 Buy
Arctom AS054326 Gambogic acid ≥98% 100mg $364 2021-12-16 Buy
AvaChem 2366 Gambogic acid 5mg $45 2021-12-16 Buy
AvaChem 2366 Gambogic acid 25mg $145 2021-12-16 Buy
AvaChem 2366 Gambogic acid 100mg $385 2021-12-16 Buy
AvaChem 2366 Gambogic acid 250mg $685 2021-12-16 Buy
AvaChem 2366 Gambogic acid 1g $1485 2021-12-16 Buy
Biorbyt Ltd orb546016 Gambogic acid >98% 5mg $173.4 2021-12-16 Buy
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Properties

Melting point :88.5°C
Boiling point :586.06°C (rough estimate)
alpha :D20 -685° (methanol)
Density :1.1057 (rough estimate)
refractive index :1.5290 (estimate)
storage temp. :-20°C
solubility :DMSO: ≥10mg/mL
form :powder
pka :4.58±0.36(Predicted)
color :yellow to orange
Stability :Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :GEZHEQNLKAOMCA-XKZIYDEJSA-N
LogP :6.490 (est)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Gambogic acid (GA) is a natural product isolated from the G. hanburyi tree that exhibits anti-cancer activity by acting on a variety of cellular pathways. In the apoptotic pathway, GA activates caspases (EC50 = 0.78 μM), inhibits binding of anti-apoptotic proteins to a BH3 peptide (IC50 = 1.47, 1.21, 2.02, 0.66, 1.06, 0.79 μM for Bcl-xL, Bcl-2, Bcl-W, Bcl-B, Bfl-1, Mcl-1, respectively), and alters expression of Bcl-2 and Bax. GA binds to the transferrin receptor (IC50 = 4.1 μM), inducing apoptosis in various tumor cell lines. It is a potent, slow inhibitor of Kir2.1 channels (IC50 = <100 nM). GA inhibits the chymotrypsin activity of the 20S proteasome in a dose-dependent manner. A novel mechanism for GA cytotoxic effects in glioma cells may be through AMPK-initiated effects on EGFR and Akt/mTORC1 signaling.

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Suppliers and manufacturers

career henan chemical co
GAMBOGIC ACID
$1.00 /1kg
GAMBOGIC ACID CAS:2752-65-0
Shanghai Standard Technology Co., Ltd.
Gambogic acid
$0.00 /20mg
Gambogic acid CAS:2752-65-0
Nanjing ChemLin Chemical Industry Co., Ltd.
Shanghai Zheyan Biotech Co., Ltd.
Chengdu Biopurify Phytochemicals Ltd.
Hubei xin bonus chemical co. LTD
BOC Sciences
Chongqing Chemdad Co., Ltd
Wuhan ChemNorm Biotech Co.,Ltd.
Hubei Ipure Biology Co., Ltd