GNE-0877
|
- $57 - $3282.7
- Product name: GNE-0877
- CAS: 1374828-69-9
- MF: C14H16F3N7
- MW: 339.32
- EINECS:-0
- MDL Number:MFCD28098661
- Synonyms:2-Methyl-2-(3-methyl-4-((4-(methylamino)-5-(trifluoromethyl)-pyrimidin-2-yl)amino)-1H-pyrazol-;GNE-0877;alpha,alpha,3-Trimethyl-4-[[4-(methylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1H-pyrazole-1-acetonitrile;2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile;alpha,alpha,3-Trimethyl-4-[[4-(methylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1H-pyrazole-1-acetonitrile GNE-0877;GNE-0877, >=98%;GNE-0877; GNE 0877; GNE0877.;CS-1275
14 prices
Selected condition：
Brand
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- DC Chemicals
- TRC
Package
- 500μg
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 100mg
- 250mg
- 1g
- 1000mg
- ManufacturerApexBio Technology
- Product numberB4633
- Product descriptionGNE0877
- Packaging2mg
- Price$173
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4633
- Product descriptionGNE0877
- Packaging5mg
- Price$284
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4633
- Product descriptionGNE0877
- Packaging10mg
- Price$465
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4633
- Product descriptionGNE0877
- Packaging25mg
- Price$1008
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181248
- Product descriptionGNE-0877 >98%
- Packaging100mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181248
- Product descriptionGNE-0877 >98%
- Packaging250mg
- Price$1654.1
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181248
- Product descriptionGNE-0877 >98%
- Packaging1000mg
- Price$3282.7
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16251
- Product descriptionGNE-0877 ≥98%
- Packaging500μg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16251
- Product descriptionGNE-0877 ≥98%
- Packaging1mg
- Price$100
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16251
- Product descriptionGNE-0877 ≥98%
- Packaging5mg
- Price$275
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM167726
- Product description2-Methyl-2-(3-methyl-4-((4-(methylamino)-5-(trifluoromethyl)-pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)propanenitrile 98%
- Packaging250mg
- Price$612
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7418
- Product descriptionGNE-0877 >98%
- Packaging100mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7418
- Product descriptionGNE-0877 >98%
- Packaging1g
- Price$2200
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberG766000
- Product descriptionGNE-0877
- Packaging5mg
- Price$205
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ApexBio Technology | B4633 | GNE0877 | 2mg | $173 | 2021-12-16 | Buy |
| ApexBio Technology | B4633 | GNE0877 | 5mg | $284 | 2021-12-16 | Buy |
| ApexBio Technology | B4633 | GNE0877 | 10mg | $465 | 2021-12-16 | Buy |
| ApexBio Technology | B4633 | GNE0877 | 25mg | $1008 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181248 | GNE-0877 >98% | 100mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181248 | GNE-0877 >98% | 250mg | $1654.1 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181248 | GNE-0877 >98% | 1000mg | $3282.7 | 2021-12-16 | Buy |
| Cayman Chemical | 16251 | GNE-0877 ≥98% | 500μg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 16251 | GNE-0877 ≥98% | 1mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 16251 | GNE-0877 ≥98% | 5mg | $275 | 2024-03-01 | Buy |
| Chemenu | CM167726 | 2-Methyl-2-(3-methyl-4-((4-(methylamino)-5-(trifluoromethyl)-pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)propanenitrile 98% | 250mg | $612 | 2021-12-16 | Buy |
| DC Chemicals | DC7418 | GNE-0877 >98% | 100mg | $600 | 2021-12-16 | Buy |
| DC Chemicals | DC7418 | GNE-0877 >98% | 1g | $2200 | 2021-12-16 | Buy |
| TRC | G766000 | GNE-0877 | 5mg | $205 | 2021-12-16 | Buy |
Properties
Melting point :121 - 122°C
Boiling point :506.3±60.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :-20°C, Inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :3.87±0.10(Predicted)
color :White to Off-White
Boiling point :506.3±60.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :-20°C, Inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :3.87±0.10(Predicted)
color :White to Off-White
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||
| Precautionary statements: |
|
Description
Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE 0877 is a selective, brain-penetrable LRRK2 inhibitor (Ki = 0.7 nM). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 3 nM in vivo.More related product prices
Losmapimod (GW856553X) Dasatinib Bortezomib Lapatinib XL413 (BMS-863233) EverolimusRelated product price
- Losmapimod (GW856553X)
$34-825 - Dasatinib
$9-4498.73 - Bortezomib
$16-1980
