K-Ras(G12C) inhibitor 9
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- $44 - $1900
- Product name: K-Ras(G12C) inhibitor 9
- CAS: 1469337-91-4
- MF: C16H21ClIN3O4S
- MW: 513.78
- EINECS:-0
- MDL Number:MFCD28143916
- Synonyms:K-Ras(G12C) inhibitor 9;N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-ethenesulfonamide;K RAS INHIBITOR-9; KRAS INHIBITOR 9;K-RAS inhibitor 9;Ethenesulfonamide, N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-;K-Ras(G12C) inhibitor 9 USP/EP/BP;K-Ras(G-12C) inhibitor 9,KRas(G12C) inhibitor 9,Ras,Inhibitor,K-Ras(G12C) inhibitor 9,inhibit,K Ras(G12C) inhibitor 9;K-Ras(GI2C) Inhibitor 9
8 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- DC Chemicals
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number2501AH
- Product descriptionK-Ras(G12C)inhibitor9
- Packaging10mg
- Price$478
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18005
- Product descriptionK-Ras(G12C) Inhibitor 9 ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18005
- Product descriptionK-Ras(G12C) Inhibitor 9 ≥98%
- Packaging5mg
- Price$193
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18005
- Product descriptionK-Ras(G12C) Inhibitor 9 ≥98%
- Packaging10mg
- Price$341
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18005
- Product descriptionK-Ras(G12C) Inhibitor 9 ≥98%
- Packaging25mg
- Price$533
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC7722
- Product descriptionK-RASinhibitor9 >98%
- Packaging250mg
- Price$700
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7722
- Product descriptionK-RASinhibitor9 >98%
- Packaging1g
- Price$1900
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberC367445
- Product descriptionN-[1-[2-[(4-Chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]ethenesulfonamide
- Packaging5mg
- Price$185
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2501AH | K-Ras(G12C)inhibitor9 | 10mg | $478 | 2021-12-16 | Buy |
| Cayman Chemical | 18005 | K-Ras(G12C) Inhibitor 9 ≥98% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 18005 | K-Ras(G12C) Inhibitor 9 ≥98% | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 18005 | K-Ras(G12C) Inhibitor 9 ≥98% | 10mg | $341 | 2024-03-01 | Buy |
| Cayman Chemical | 18005 | K-Ras(G12C) Inhibitor 9 ≥98% | 25mg | $533 | 2024-03-01 | Buy |
| DC Chemicals | DC7722 | K-RASinhibitor9 >98% | 250mg | $700 | 2021-12-16 | Buy |
| DC Chemicals | DC7722 | K-RASinhibitor9 >98% | 1g | $1900 | 2021-12-16 | Buy |
| TRC | C367445 | N-[1-[2-[(4-Chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]ethenesulfonamide | 5mg | $185 | 2021-12-16 | Buy |
Properties
Boiling point :656.3±65.0 °C(Predicted)
Density :1.68±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :crystalline solid
pka :9.68±0.20(Predicted)
color :White to off-white
Density :1.68±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :crystalline solid
pka :9.68±0.20(Predicted)
color :White to off-white
Safety Information
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Description
K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 μM for 24 hours in vitro. K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis.Related product price
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