LL-Z-1640-2
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- $105 - $1174.17
- Product name: LL-Z-1640-2
- CAS: 66018-38-0
- MF: C19H22O7
- MW: 362.37
- EINECS:
- MDL Number:MFCD12912700
- Synonyms:(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione;(5Z)-7-Oxozeaenol;JNK/p38 inhibitor;C292, L 783278;LL-Z-1640-2;(5Z)-7-Oxozeaenol (5Z-7-oxozeaenol);5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione
7 prices
Selected condition：
Brand
- Alfa Aesar
- American Custom Chemicals Corporation
- Sigma-Aldrich
- Tocris
- TRC
Package
- 1
- 1mg
- 5mg
- 10MG
- ManufacturerAlfa Aesar
- Product numberJ66651
- Product description5Z-7-Oxozeaenol
- Packaging1mg
- Price$125.65
- Updated2024-03-01
- Buy
- ManufacturerAlfa Aesar
- Product numberJ66651
- Product description5Z-7-Oxozeaenol
- Packaging5mg
- Price$509.65
- Updated2024-03-01
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0014467
- Product descriptionLL-Z-1640-2 95.00%
- Packaging5MG
- Price$1016.64
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0014467
- Product descriptionLL-Z-1640-2 95.00%
- Packaging10MG
- Price$1174.17
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number499610
- Product description(5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem
(5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC = 8 nM). - Packaging1mg
- Price$159
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number3604
- Product description(5Z)-7-Oxozeaenol ≥98%(HPLC)
- Packaging1
- Price$176
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberA697425
- Product descriptionAntibioticLLZ1640-2
- Packaging1mg
- Price$105
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Alfa Aesar | J66651 | 5Z-7-Oxozeaenol | 1mg | $125.65 | 2024-03-01 | Buy |
| Alfa Aesar | J66651 | 5Z-7-Oxozeaenol | 5mg | $509.65 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | CHM0014467 | LL-Z-1640-2 95.00% | 5MG | $1016.64 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0014467 | LL-Z-1640-2 95.00% | 10MG | $1174.17 | 2021-12-16 | Buy |
| Sigma-Aldrich | 499610 | (5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem (5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC = 8 nM). |
1mg | $159 | 2024-03-01 | Buy |
| Tocris | 3604 | (5Z)-7-Oxozeaenol ≥98%(HPLC) | 1 | $176 | 2021-12-16 | Buy |
| TRC | A697425 | AntibioticLLZ1640-2 | 1mg | $105 | 2021-12-16 | Buy |
Properties
storage temp. :Desiccate at -20°C
solubility :Soluble in DMSO
form :White solid
solubility :Soluble in DMSO
form :White solid
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Antibiotic LL Z1640-2 is a signal-specific inhibitor of the JNK/p38 pathways that has been shown to inhibit anisomycin-induced but not TNF-induced JNK/p38 activation. Shown to inhibit HgCl2 and CdCl2 MAPKs activation, while not affecting total protein level, in CCRF-CEM and NIH3T3 cells, respectively. Like other members of the resorcylic acid lactone (RAL) family, LL-Z1640-2 targets the ATP-binding pocket of kinases. Unlike other RALs, irreversibly inhibits TAK1. This cis-enone resorcylic acid lactone was first reported in 1978 and later rediscovered as an irreversible and highly selective TAK1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines.Related product price
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