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ChemicalBook >> CAS DataBase List >> MLN9708

MLN9708

MLN9708 price.
  • $28 - $10065.83
  • Product name: MLN9708
  • CAS: 1201902-80-8
  • MF: C20H23BCl2N2O9
  • MW: 517.12
  • EINECS:-0
  • MDL Number:MFCD18251437
  • Synonyms:4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid;MLN9708;MLN9708,MLN-9708,MLN 9708;4-Carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-acetic acid;4-Carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-acetic acid MLN9708;Ixazomib Citrate;MLN9708;MLN-9708;4-(Carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dio
18 prices
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Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Ark Pharm
  • Axon Medchem
  • Cayman Chemical
  • Crysdot
  • TRC
Package
  • 1unit
  • 1mg
  • 2mg
  • 5mg
  • 10MG
  • 2x5mg
  • 20mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1G
  • ManufacturerAK Scientific
  • Product numberX7548
  • Product descriptionMLN9708
  • Packaging5mg
  • Price$170
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7548
  • Product descriptionMLN9708
  • Packaging250mg
  • Price$420
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000901
  • Product descriptionMLN-9708 95.00%
  • Packaging10MG
  • Price$1006.58
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000901
  • Product descriptionMLN-9708 95.00%
  • Packaging1G
  • Price$10065.83
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4007
  • Product descriptionMLN9708
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60408
  • Product descriptionIxazomibCitrate(MLN9708)
  • Packaging20mg
  • Price$258
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000022748
  • Product descriptionIxazomib citrate 98+%
  • Packaging2mg
  • Price$96
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000022748
  • Product descriptionIxazomib citrate 98+%
  • Packaging5mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000022748
  • Product descriptionIxazomib citrate 98+%
  • Packaging10mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000022748
  • Product descriptionIxazomib citrate 98+%
  • Packaging50mg
  • Price$654
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000022748
  • Product descriptionIxazomib citrate 98+%
  • Packaging100mg
  • Price$916
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2557
  • Product descriptionMLN9708-Ixazomibcitrate 99%
  • Packaging2x5mg
  • Price$165
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18386
  • Product descriptionMLN9708 ≥95%
  • Packaging1mg
  • Price$43
  • Updated2023-06-20
  • Buy
  • ManufacturerCayman Chemical
  • Product number18386
  • Product descriptionMLN9708 ≥95%
  • Packaging5mg
  • Price$60
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18386
  • Product descriptionMLN9708 ≥95%
  • Packaging10mg
  • Price$89
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18386
  • Product descriptionMLN9708 ≥95%
  • Packaging50mg
  • Price$208
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7548 MLN9708 5mg $170 2021-12-16 Buy
AK Scientific X7548 MLN9708 250mg $420 2021-12-16 Buy
American Custom Chemicals Corporation INB0000901 MLN-9708 95.00% 10MG $1006.58 2021-12-16 Buy
American Custom Chemicals Corporation INB0000901 MLN-9708 95.00% 1G $10065.83 2021-12-16 Buy
ApexBio Technology A4007 MLN9708 1unit $28 2021-12-16 Buy
Arctom CFN60408 IxazomibCitrate(MLN9708) 20mg $258 2021-12-16 Buy
Ark Pharm P000022748 Ixazomib citrate 98+% 2mg $96 2021-12-16 Buy
Ark Pharm P000022748 Ixazomib citrate 98+% 5mg $144 2021-12-16 Buy
Ark Pharm P000022748 Ixazomib citrate 98+% 10mg $218 2021-12-16 Buy
Ark Pharm P000022748 Ixazomib citrate 98+% 50mg $654 2021-12-16 Buy
Ark Pharm P000022748 Ixazomib citrate 98+% 100mg $916 2021-12-16 Buy
Axon Medchem Axon2557 MLN9708-Ixazomibcitrate 99% 2x5mg $165 2021-12-16 Buy
Cayman Chemical 18386 MLN9708 ≥95% 1mg $43 2023-06-20 Buy
Cayman Chemical 18386 MLN9708 ≥95% 5mg $60 2024-03-01 Buy
Cayman Chemical 18386 MLN9708 ≥95% 10mg $89 2024-03-01 Buy
Cayman Chemical 18386 MLN9708 ≥95% 50mg $208 2024-03-01 Buy

Properties

Melting point :>227°C (dec.)
Density :1.47
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
pka :1.92±0.20(Predicted)
form :Solid
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

MLN9708 is an orally bioavailable prodrug of the second-generation proteasome inhibitor MLN2239 . This prodrug rapidly hydrolyzes in plasma to the biologically active form, which inhibits the β5 chymotryptic-like subunit of the 20S proteasome (IC50 = 3.4 nM; Ki = 0.93 nM in cell-free assays). It inhibits the β1 caspase-like and β2 trypsin-like proteolytic sites with IC50 values of 0.03 and 3.5 μM, respectively. MLN9708 has shown antitumor activity both in cell-based assays and in xenograft models and has been examined in phase III clinical trials for potential antimyeloma activity.

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