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ChemicalBook >> CAS DataBase List >> CEP-18770

CEP-18770

CEP-18770 price.
  • $32 - $3400
  • Product name: CEP-18770
  • CAS: 847499-27-8
  • MF: C21H28BN3O5
  • MW: 413.28
  • EINECS:
  • MDL Number:MFCD18251439
  • Synonyms:CEP-18770;[(1R)-1-[[(2S,3R)-3-Hydroxy-2-[[(6-phenylpyridin-2-yl)carbonyl]amino]-1-oxobutyl]amino]-3-methylbutyl]boronic acid;CIP 18770;CT 47098;Delanzomib;NPH 007098;CEP-18770 (DelanzoMib);DelanzoMib, Free Base, >99%
24 prices
Selected condition:
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 10mM(in 1mL DMSO)
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3673-M025
  • Product descriptionDelanzomib[CEP-18770] ≥95%(1H-NMR)
  • Packaging25mg
  • Price$380
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2309AH
  • Product description((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutyl)boronicacid
  • Packaging1mg
  • Price$133
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2309AH
  • Product description((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutyl)boronicacid
  • Packaging5mg
  • Price$235
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2309AH
  • Product description((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutyl)boronicacid
  • Packaging10mg
  • Price$336
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2309AH
  • Product description((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutyl)boronicacid
  • Packaging50mg
  • Price$1112
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0013851
  • Product descriptionCEP-18770 95.00%
  • Packaging10MG
  • Price$342.3
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4009
  • Product descriptionCEP-18770
  • Packaging5mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4009
  • Product descriptionCEP-18770
  • Packaging10mM(in 1mL DMSO)
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4009
  • Product descriptionCEP-18770
  • Packaging10mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4009
  • Product descriptionCEP-18770
  • Packaging50mg
  • Price$640
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4009
  • Product descriptionCEP-18770
  • Packaging100mg
  • Price$950
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number23557
  • Product descriptionDelanzomib ≥95%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23557
  • Product descriptionDelanzomib ≥95%
  • Packaging5mg
  • Price$122
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23557
  • Product descriptionDelanzomib ≥95%
  • Packaging10mg
  • Price$214
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23557
  • Product descriptionDelanzomib ≥95%
  • Packaging50mg
  • Price$911
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1624
  • Product descriptionDelanzomib ≥98.0%
  • Packaging5mg
  • Price$150
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3673-M025 Delanzomib[CEP-18770] ≥95%(1H-NMR) 25mg $380 2021-12-16 Buy
AK Scientific 2309AH ((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutyl)boronicacid 1mg $133 2021-12-16 Buy
AK Scientific 2309AH ((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutyl)boronicacid 5mg $235 2021-12-16 Buy
AK Scientific 2309AH ((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutyl)boronicacid 10mg $336 2021-12-16 Buy
AK Scientific 2309AH ((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutyl)boronicacid 50mg $1112 2021-12-16 Buy
American Custom Chemicals Corporation API0013851 CEP-18770 95.00% 10MG $342.3 2021-12-16 Buy
ApexBio Technology A4009 CEP-18770 5mg $105 2021-12-16 Buy
ApexBio Technology A4009 CEP-18770 10mM(in 1mL DMSO) $138 2021-12-16 Buy
ApexBio Technology A4009 CEP-18770 10mg $180 2021-12-16 Buy
ApexBio Technology A4009 CEP-18770 50mg $640 2021-12-16 Buy
ApexBio Technology A4009 CEP-18770 100mg $950 2021-12-16 Buy
Cayman Chemical 23557 Delanzomib ≥95% 1mg $32 2024-03-01 Buy
Cayman Chemical 23557 Delanzomib ≥95% 5mg $122 2024-03-01 Buy
Cayman Chemical 23557 Delanzomib ≥95% 10mg $214 2024-03-01 Buy
Cayman Chemical 23557 Delanzomib ≥95% 50mg $911 2024-03-01 Buy
ChemScene CS-1624 Delanzomib ≥98.0% 5mg $150 2021-12-16 Buy

Properties

Melting point :178-190°C (dec.)
Density :1.207
storage temp. :Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility :Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
form :Solid
pka :9.67±0.43(Predicted)
color :White to Off-White
Stability :Hygroscopic

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Delanzomib is an orally bioavailable inhibitor of chymotrypsin-like proteasome activity (IC50 = 3.8 nM in isolated human erythrocytes) that only marginally inhibits tryptic and peptidyl glutamyl proteasome activity. Delanzomib pre-treatment (20 nM) in vitro inhibits IκBα degradation, NF-κB activation, and the expression of NF-κB-regulated genes, including IκBα, XIAP, TNF-α, IL-1β, ICAM-1, and VEGF. Delanzomib induces apoptosis in multiple myeloma cell lines and inhibits proliferation in a panel of human hematologic and solid tumor cell lines (IC50s = 5.6-34.2 nM). It reduces tumor weight in an RPMI 8226 human multiple myeloma mouse xenograft model when administered intravenously at doses ranging from 1.5-4 mg/kg twice daily and leads to complete tumor regression at a chronic oral dose of 13 mg/kg. Delanzomib reduces the serum level of circulating cytokines, prevents renal tissue damage, and increases lifespan in a mouse model of fatal lupus nephritis.

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