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ChemicalBook >> CAS DataBase List >> GDC-0623

GDC-0623

GDC-0623 price.
  • $41 - $2500
  • Product name: GDC-0623
  • CAS: 1168091-68-6
  • MF: C16H14FIN4O3
  • MW: 456.21
  • EINECS:604-604-1
  • MDL Number:MFCD25976760
  • Synonyms:RG 7421;5-(2-Fluoro-4-iodophenylamino)imidazo[1,5-a]pyridine-6-carboxylic acid N-(2-hydroxyethoxy)amide;GDC-0623 (5-((2-Fluoro-4-Iodophenyl)amino)-N-(2-Hydroxyethoxy)imidazo[1,5-a]pyridine-6-Carboxamide);5-(2-Fluoro-4-iodophenylamino)imidazo[1,5-a]pyridine-6-carboxylic acid N-(2-hydroxyethoxy)amide RG 7421 GDC-0623;GDC-0623;MEK inhibitor 1;G-868;5-((2-FLUORO-4-IODOPHENYL)AMINO)-N-(2-HYDROXYETHOXY)IMIDAZO[1,5-A]PYRIDINE-6-CARBOXAMIDE
17 prices
Selected condition:
Brand
  • AK Scientific
  • ApexBio Technology
  • Apolloscientific
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Crysdot
  • DC Chemicals
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1g
  • ManufacturerAK Scientific
  • Product number9855DD
  • Product descriptionGdc-0623
  • Packaging10mg
  • Price$313
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1135
  • Product descriptionGDC-0623
  • Packaging5mg
  • Price$124
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0174
  • Product descriptionGDC-0623
  • Packaging5mg
  • Price$189
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0174
  • Product descriptionGDC-0623
  • Packaging10mg
  • Price$291
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0174
  • Product descriptionGDC-0623
  • Packaging50mg
  • Price$756
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFG103137
  • Product descriptionGDC 0623
  • Packaging10mg
  • Price$195
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFG103137
  • Product descriptionGDC 0623
  • Packaging50mg
  • Price$682.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19479
  • Product descriptionGDC-0623 ≥98%
  • Packaging1mg
  • Price$41
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19479
  • Product descriptionGDC-0623 ≥98%
  • Packaging5mg
  • Price$121
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19479
  • Product descriptionGDC-0623 ≥98%
  • Packaging10mg
  • Price$201
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19479
  • Product descriptionGDC-0623 ≥98%
  • Packaging25mg
  • Price$302
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM151435
  • Product description5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide 98%
  • Packaging100mg
  • Price$439
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004427
  • Product descriptionGDC-0623 98+%
  • Packaging10mg
  • Price$278
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004427
  • Product descriptionGDC-0623 98+%
  • Packaging50mg
  • Price$687
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004427
  • Product descriptionGDC-0623 98+%
  • Packaging100mg
  • Price$926
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8000
  • Product descriptionGDC-0623 >98%
  • Packaging1g
  • Price$2500
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9855DD Gdc-0623 10mg $313 2021-12-16 Buy
ApexBio Technology B1135 GDC-0623 5mg $124 2021-12-16 Buy
Apolloscientific BISN0174 GDC-0623 5mg $189 2021-12-16 Buy
Apolloscientific BISN0174 GDC-0623 10mg $291 2021-12-16 Buy
Apolloscientific BISN0174 GDC-0623 50mg $756 2021-12-16 Buy
Biosynth Carbosynth FG103137 GDC 0623 10mg $195 2021-12-16 Buy
Biosynth Carbosynth FG103137 GDC 0623 50mg $682.5 2021-12-16 Buy
Cayman Chemical 19479 GDC-0623 ≥98% 1mg $41 2024-03-01 Buy
Cayman Chemical 19479 GDC-0623 ≥98% 5mg $121 2024-03-01 Buy
Cayman Chemical 19479 GDC-0623 ≥98% 10mg $201 2024-03-01 Buy
Cayman Chemical 19479 GDC-0623 ≥98% 25mg $302 2024-03-01 Buy
Chemenu CM151435 5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide 98% 100mg $439 2021-12-16 Buy
Crysdot CD31004427 GDC-0623 98+% 10mg $278 2021-12-16 Buy
Crysdot CD31004427 GDC-0623 98+% 50mg $687 2021-12-16 Buy
Crysdot CD31004427 GDC-0623 98+% 100mg $926 2021-12-16 Buy
DC Chemicals DC8000 GDC-0623 >98% 1g $2500 2021-12-16 Buy

Properties

Density :1.81±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥16.85 mg/mL in DMSO; ≥2.69 mg/mL in EtOH with ultrasonic
form :solid
pka :14.17±0.10(Predicted)
color :Light yellow to gray

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki = 0.13 nM in the presence of ATP). It inhibits the proliferation of A375 BRAF(V600E) and HCT116 KRAS(G13D)-mutant cancer cell lines with EC50 values of 7 and 42 nM, respectively. GDC-0623 inhibits ERK and BIM phosphorylation resulting in upregulation and stabilization of pro-apoptotic BIM protein in KRAS mutant and wild-type HCT116 cells and in KRAS mutant GW620 cells.

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