Welcome to chemicalbook!
China English Japan Germany
400-158-6606
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
Structured search
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook My chemicalbook

Welcome back!

RFQ
skype
MY Account
Top
ChemicalBook >> CAS DataBase List >> GDC-0623

GDC-0623

GDC-0623 price.
  • $41 - $2500
  • Product name: GDC-0623
  • CAS: 1168091-68-6
  • MF: C16H14FIN4O3
  • MW: 456.21
  • EINECS:604-604-1
  • MDL Number:MFCD25976760
  • Synonyms:RG 7421;5-(2-Fluoro-4-iodophenylamino)imidazo[1,5-a]pyridine-6-carboxylic acid N-(2-hydroxyethoxy)amide;GDC-0623 (5-((2-Fluoro-4-Iodophenyl)amino)-N-(2-Hydroxyethoxy)imidazo[1,5-a]pyridine-6-Carboxamide);5-(2-Fluoro-4-iodophenylamino)imidazo[1,5-a]pyridine-6-carboxylic acid N-(2-hydroxyethoxy)amide RG 7421 GDC-0623;GDC-0623;MEK inhibitor 1;G-868;5-((2-FLUORO-4-IODOPHENYL)AMINO)-N-(2-HYDROXYETHOXY)IMIDAZO[1,5-A]PYRIDINE-6-CARBOXAMIDE
Price17 Properties Safety Information Description
17 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Apolloscientific
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Crysdot
  • DC Chemicals
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1g
  • ManufacturerAK Scientific
  • Product number9855DD
  • Product descriptionGdc-0623
  • Packaging10mg
  • Price$313
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1135
  • Product descriptionGDC-0623
  • Packaging5mg
  • Price$124
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0174
  • Product descriptionGDC-0623
  • Packaging5mg
  • Price$189
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0174
  • Product descriptionGDC-0623
  • Packaging10mg
  • Price$291
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0174
  • Product descriptionGDC-0623
  • Packaging50mg
  • Price$756
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFG103137
  • Product descriptionGDC 0623
  • Packaging10mg
  • Price$195
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFG103137
  • Product descriptionGDC 0623
  • Packaging50mg
  • Price$682.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19479
  • Product descriptionGDC-0623 ≥98%
  • Packaging1mg
  • Price$41
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19479
  • Product descriptionGDC-0623 ≥98%
  • Packaging5mg
  • Price$121
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19479
  • Product descriptionGDC-0623 ≥98%
  • Packaging10mg
  • Price$201
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19479
  • Product descriptionGDC-0623 ≥98%
  • Packaging25mg
  • Price$302
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM151435
  • Product description5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide 98%
  • Packaging100mg
  • Price$439
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004427
  • Product descriptionGDC-0623 98+%
  • Packaging10mg
  • Price$278
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004427
  • Product descriptionGDC-0623 98+%
  • Packaging50mg
  • Price$687
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004427
  • Product descriptionGDC-0623 98+%
  • Packaging100mg
  • Price$926
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8000
  • Product descriptionGDC-0623 >98%
  • Packaging1g
  • Price$2500
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9855DD Gdc-0623 10mg $313 2021-12-16 Buy
ApexBio Technology B1135 GDC-0623 5mg $124 2021-12-16 Buy
Apolloscientific BISN0174 GDC-0623 5mg $189 2021-12-16 Buy
Apolloscientific BISN0174 GDC-0623 10mg $291 2021-12-16 Buy
Apolloscientific BISN0174 GDC-0623 50mg $756 2021-12-16 Buy
Biosynth Carbosynth FG103137 GDC 0623 10mg $195 2021-12-16 Buy
Biosynth Carbosynth FG103137 GDC 0623 50mg $682.5 2021-12-16 Buy
Cayman Chemical 19479 GDC-0623 ≥98% 1mg $41 2024-03-01 Buy
Cayman Chemical 19479 GDC-0623 ≥98% 5mg $121 2024-03-01 Buy
Cayman Chemical 19479 GDC-0623 ≥98% 10mg $201 2024-03-01 Buy
Cayman Chemical 19479 GDC-0623 ≥98% 25mg $302 2024-03-01 Buy
Chemenu CM151435 5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide 98% 100mg $439 2021-12-16 Buy
Crysdot CD31004427 GDC-0623 98+% 10mg $278 2021-12-16 Buy
Crysdot CD31004427 GDC-0623 98+% 50mg $687 2021-12-16 Buy
Crysdot CD31004427 GDC-0623 98+% 100mg $926 2021-12-16 Buy
DC Chemicals DC8000 GDC-0623 >98% 1g $2500 2021-12-16 Buy
Next Last

Properties

Density :1.81±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥16.85 mg/mL in DMSO; ≥2.69 mg/mL in EtOH with ultrasonic
form :solid
pka :14.17±0.10(Predicted)
color :Light yellow to gray

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki = 0.13 nM in the presence of ATP). It inhibits the proliferation of A375 BRAF(V600E) and HCT116 KRAS(G13D)-mutant cancer cell lines with EC50 values of 7 and 42 nM, respectively. GDC-0623 inhibits ERK and BIM phosphorylation resulting in upregulation and stabilization of pro-apoptotic BIM protein in KRAS mutant and wild-type HCT116 cells and in KRAS mutant GW620 cells.

More related product prices

4-iodo-3-nitrobenzamide GDC-0879 HTH-01-015 AZ191 2-((2-Chlorophenyl)(phenyl)aMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide LJI308 CEP-18770 IMR-1 CPI-455

Related product price

Suppliers and manufacturers

Career Henan Chemica Co
ATK CHEMICAL COMPANY LIMITED
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Hangzhou MolCore BioPharmatech Co.,Ltd.
Nantong HI-FUTURE Biology Co., Ltd.
TargetMol Chemicals Inc.
Aladdin Scientific
Amadis Chemical Company Limited NCE Biomedical Co.,Ltd.