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ChemicalBook >> CAS DataBase List >> CPI-455

CPI-455

CPI-455 price.
  • $26 - $1700
  • Product name: CPI-455
  • CAS: 1628208-23-0
  • MF: C16H14N4O
  • MW: 278.31
  • EINECS:-0
  • MDL Number:MFCD29921343
  • Synonyms:CPI-455;6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile;CPI 455;CPI455;CPI 455;CPI-455;CPI455;CPI-455, >98%;CPI-455(free base);Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,7-dihydro-6-(1-methylethyl)-7-oxo-5-phenyl-;CPI 455,Histone Demethylase,CPI455,CPI-455,Inhibitor,inhibit
Price18 Properties Safety Information Description
18 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Axon Medchem
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 2x25mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number1814DY
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile
  • Packaging5mg
  • Price$289
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7811
  • Product description6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride
  • Packaging5mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7811
  • Product description6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride
  • Packaging25mg
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2573
  • Product descriptionCPI455 99%
  • Packaging2x25mg
  • Price$572
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number22127
  • Product descriptionCPI-455 ≥98%
  • Packaging1mg
  • Price$26
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22127
  • Product descriptionCPI-455 ≥98%
  • Packaging5mg
  • Price$90
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22127
  • Product descriptionCPI-455 ≥98%
  • Packaging10mg
  • Price$153
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22127
  • Product descriptionCPI-455 ≥98%
  • Packaging25mg
  • Price$320
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM250011
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 97%
  • Packaging250mg
  • Price$281
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6133
  • Product descriptionCPI-455 98.95%
  • Packaging5mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6133
  • Product descriptionCPI-455 98.95%
  • Packaging10mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6133
  • Product descriptionCPI-455 98.95%
  • Packaging25mg
  • Price$396
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6133
  • Product descriptionCPI-455 98.95%
  • Packaging50mg
  • Price$720
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6133
  • Product descriptionCPI-455 98.95%
  • Packaging100mg
  • Price$1200
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11242980
  • Product descriptionCPI-455 97%
  • Packaging25mg
  • Price$375
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11242980
  • Product descriptionCPI-455 97%
  • Packaging50mg
  • Price$681
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1814DY 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 5mg $289 2021-12-16 Buy
ApexBio Technology B7811 6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride 5mg $85 2021-12-16 Buy
ApexBio Technology B7811 6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride 25mg $320 2021-12-16 Buy
Axon Medchem Axon2573 CPI455 99% 2x25mg $572 2021-12-16 Buy
Cayman Chemical 22127 CPI-455 ≥98% 1mg $26 2024-03-01 Buy
Cayman Chemical 22127 CPI-455 ≥98% 5mg $90 2024-03-01 Buy
Cayman Chemical 22127 CPI-455 ≥98% 10mg $153 2024-03-01 Buy
Cayman Chemical 22127 CPI-455 ≥98% 25mg $320 2024-03-01 Buy
Chemenu CM250011 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 97% 250mg $281 2021-12-16 Buy
ChemScene CS-6133 CPI-455 98.95% 5mg $108 2021-12-16 Buy
ChemScene CS-6133 CPI-455 98.95% 10mg $180 2021-12-16 Buy
ChemScene CS-6133 CPI-455 98.95% 25mg $396 2021-12-16 Buy
ChemScene CS-6133 CPI-455 98.95% 50mg $720 2021-12-16 Buy
ChemScene CS-6133 CPI-455 98.95% 100mg $1200 2021-12-16 Buy
Crysdot CD11242980 CPI-455 97% 25mg $375 2021-12-16 Buy
Crysdot CD11242980 CPI-455 97% 50mg $681 2021-12-16 Buy
Next Last

Properties

Boiling point :488.7±55.0 °C(Predicted)
Density :1.28±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :solid
pka :-5.10±0.60(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310 Immediately call a POISON CENTER or doctor/physician.

Description

CPI-455 (1628208-23-0) is a potent (IC50?= 10 nM) and selective inhibitor of the lysine demethylase KDM5 (equal inhibition of KDM5A, 5B, 5C).1?CPI-455 reduced the number of drug-tolerant persister cancer cells (DTPs) in a dose-dependent, KDM5-dependent manner in multiple cell lines treated with standard chemotherapy or targeted agents. CPI-455 synergized with 5-aza-2’-deoxycytidine (DAC) to reduce the viability of luminal breast cancer cells?in vitro.2?KDM5 demethylases have recently been shown to repress the immune response to tumors?via?suppression of STING.3

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Suppliers and manufacturers

career henan chemical co
CPI-455
$1.00 /1ASSAYS
CPI-455 CAS:1628208-23-0
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