PIPERLONGUMINE
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- $26 - $1963.5
- Product name: PIPERLONGUMINE
- CAS: 20069-09-4
- MF: C17H19NO5
- MW: 317.34
- EINECS:
- MDL Number:MFCD00075706
- Synonyms:PIPERLONGUMIN;PIPERLONGUMINE;PIPLARTINE;5,6-DIHYDRO-1-[1-OXO-3-3,4,5-TRIMETHOXYPHENYL-TRANS-2-PROPENYL]-21H-PYRIDINONE;piperlongumine from long pepper;(E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one;PPLGM;1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one
54 prices
Selected condition：
Brand
- A1 Biochem Labs
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- BroadPharm
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 10mg
- 20mg
- 5mg
- 10
- 25mg
- 50mg
- 100mg
- 250mg
- 50
- 500mg
- 1g
- 10mM(in 1mL DMSO)
- ManufacturerA1 Biochem Labs
- Product number6563789
- Product descriptionPiperlongumine 96%
- Packaging500mg
- Price$275
- Updated2021-12-16
- Buy
- ManufacturerA1 Biochem Labs
- Product number6563789
- Product descriptionPiperlongumine 96%
- Packaging1g
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0024-M010
- Product descriptionPiperlongumine ≥97%
- Packaging10mg
- Price$30
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2659AH
- Product descriptionPiperlongumine
- Packaging1g
- Price$770
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA250732
- Product description(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 98%
- Packaging5mg
- Price$26
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA250732
- Product description(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 98%
- Packaging10mg
- Price$38
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA250732
- Product description(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 98%
- Packaging25mg
- Price$58
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA250732
- Product description(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 98%
- Packaging50mg
- Price$76
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA250732
- Product description(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 98%
- Packaging100mg
- Price$106
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA250732
- Product description(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 98%
- Packaging250mg
- Price$226
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA250732
- Product description(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 98%
- Packaging1g
- Price$758
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0031863
- Product descriptionPiperlongumine 95.00%
- Packaging10MG
- Price$750.75
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0031863
- Product descriptionPiperlongumine 95.00%
- Packaging100MG
- Price$1963.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4455
- Product descriptionPiperlongumine
- Packaging10mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4455
- Product descriptionPiperlongumine
- Packaging10mM(in 1mL DMSO)
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4455
- Product descriptionPiperlongumine
- Packaging50mg
- Price$180
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| A1 Biochem Labs | 6563789 | Piperlongumine 96% | 500mg | $275 | 2021-12-16 | Buy |
| A1 Biochem Labs | 6563789 | Piperlongumine 96% | 1g | $400 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CN2-0024-M010 | Piperlongumine ≥97% | 10mg | $30 | 2021-12-16 | Buy |
| AK Scientific | 2659AH | Piperlongumine | 1g | $770 | 2021-12-16 | Buy |
| Ambeed | A250732 | (E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 98% | 5mg | $26 | 2021-12-16 | Buy |
| Ambeed | A250732 | (E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 98% | 10mg | $38 | 2021-12-16 | Buy |
| Ambeed | A250732 | (E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 98% | 25mg | $58 | 2021-12-16 | Buy |
| Ambeed | A250732 | (E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 98% | 50mg | $76 | 2021-12-16 | Buy |
| Ambeed | A250732 | (E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 98% | 100mg | $106 | 2021-12-16 | Buy |
| Ambeed | A250732 | (E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 98% | 250mg | $226 | 2021-12-16 | Buy |
| Ambeed | A250732 | (E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 98% | 1g | $758 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0031863 | Piperlongumine 95.00% | 10MG | $750.75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0031863 | Piperlongumine 95.00% | 100MG | $1963.5 | 2021-12-16 | Buy |
| ApexBio Technology | A4455 | Piperlongumine | 10mg | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A4455 | Piperlongumine | 10mM(in 1mL DMSO) | $60 | 2021-12-16 | Buy |
| ApexBio Technology | A4455 | Piperlongumine | 50mg | $180 | 2021-12-16 | Buy |
Properties
Melting point :124°C
Boiling point :475.6±45.0 °C(Predicted)
Density :1.223±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥5mg/mL at warmed to 60°C
pka :-1.88±0.20(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
LogP :2.340 (est)
Boiling point :475.6±45.0 °C(Predicted)
Density :1.223±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥5mg/mL at warmed to 60°C
pka :-1.88±0.20(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
LogP :2.340 (est)
Safety Information
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Description
Cancer cell survival appears partly dependent on antioxidative enzymes, whose expression is regulated by the Keap1-Nrf2 pathway, to quench potentially toxic reactive oxygen species (ROS) generated by their metastatic transformation. Piperlongumine, isolated from the Piper longum L. plant, is a small molecule that selectively increases the level of reactive oxygen species (ROS) and apoptosis in cancer cells but not in normal cells. At concentrations less than 15 μM, piperlongumine induces cell death, upregulating proapoptotic genes, and repressing pro-survival genes. In established bladder, breast, lung, and melanoma tumor xenografts in mice, piperlongumine administered daily at 2.4 mg/kg for 2 weeks inhibits tumor growth and angiogenesis. Piperlongumine increases ROS in both cancer cells and normal cells engineered to have a cancer geneotype by selectively binding to proteins known to regulate redox and ROS homeostasis. Previously, piperlongumine has been used as a crude treatment to improve poor blood circulation. It affects platelet function in rabbits by inhibiting platelet aggregation induced by the thromboxane A2 agonist U-46619 with a Ki value of 6.8 μM.More related product prices
VERATRIDINERelated product price
- VERATRIDINE
$0-1440 - N,N-DIETHYLACRYLAMIDE
$10-460 - PIPERLONGUMINE
$26-1963.5
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