RN-1 (hydrochloride)
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- $57 - $1800
- Product name: RN-1 (hydrochloride)
- CAS: 1781835-13-9
- MF: C23H30ClN3O2
- MW: 415.96
- EINECS:
- MDL Number:MFCD32200435
- Synonyms:RN-1 (hydrochloride);1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride;RN 1 dihydrochloride;RN1; RN 1;disease,RN1,RN 1 dihydrochloride,Histone Demethylase,inhibit,hemoglobin,fetal,RN1 dihydrochloride,brain-penetrant,LSD1,Inhibitor,HbF,sickle,RN 1,cell,RN-1,irreversible
10 prices
Selected condition：
Brand
- ApexBio Technology
- Cayman Chemical
- DC Chemicals
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 50
- 10mg
- 250mg
- 1g
- ManufacturerApexBio Technology
- Product numberC4247
- Product descriptionRN-1(hydrochloride)
- Packaging5mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18124
- Product descriptionRN-1 (hydrochloride) ≥95%
- Packaging1mg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18124
- Product descriptionRN-1 (hydrochloride) ≥95%
- Packaging5mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18124
- Product descriptionRN-1 (hydrochloride) ≥95%
- Packaging10mg
- Price$216
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC7636
- Product descriptionRN-1Hydrochloride >98%
- Packaging250mg
- Price$900
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7636
- Product descriptionRN-1Hydrochloride >98%
- Packaging1g
- Price$1800
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number4977
- Product descriptionRN1dihydrochloride ≥97%(HPLC)
- Packaging10
- Price$223
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number4977
- Product descriptionRN1dihydrochloride ≥97%(HPLC)
- Packaging50
- Price$936
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberR636000
- Product descriptionRN-1Hydrochloride
- Packaging10mg
- Price$170
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number256465
- Product descriptionRN 1 dihydrochloride
- Packaging10mg
- Price$475
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ApexBio Technology | C4247 | RN-1(hydrochloride) | 5mg | $150 | 2021-12-16 | Buy |
| Cayman Chemical | 18124 | RN-1 (hydrochloride) ≥95% | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 18124 | RN-1 (hydrochloride) ≥95% | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 18124 | RN-1 (hydrochloride) ≥95% | 10mg | $216 | 2024-03-01 | Buy |
| DC Chemicals | DC7636 | RN-1Hydrochloride >98% | 250mg | $900 | 2021-12-16 | Buy |
| DC Chemicals | DC7636 | RN-1Hydrochloride >98% | 1g | $1800 | 2021-12-16 | Buy |
| Tocris | 4977 | RN1dihydrochloride ≥97%(HPLC) | 10 | $223 | 2021-12-16 | Buy |
| Tocris | 4977 | RN1dihydrochloride ≥97%(HPLC) | 50 | $936 | 2021-12-16 | Buy |
| TRC | R636000 | RN-1Hydrochloride | 10mg | $170 | 2021-12-16 | Buy |
| Usbiological | 256465 | RN 1 dihydrochloride | 10mg | $475 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :insoluble in EtOH; ≥2.7 mg/mL in DMSO with ultrasonic; ≥8.47 mg/mL in H2O
form :crystalline solid
color :White to off-white
solubility :insoluble in EtOH; ≥2.7 mg/mL in DMSO with ultrasonic; ≥8.47 mg/mL in H2O
form :crystalline solid
color :White to off-white
Safety Information
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Description
Lysine-specific demethylase 1 (LSD1) belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases that include monoamine oxidases (MAOs). RN-1 is a potent, irreversible inhibitor of LSD1 (IC50 = 70 nM). It is much less effective against MAO-A and MAO-B (IC50s = 0.51 and 2.8 μM, respectively). Following intraperitoneal administration, RN-1 penetrates the blood-brain barrier and distributes in mice to a brain/plasma exposure ratio of 88.9. It blocks long-term but not short-term memory in mice. RN-1 also induces cytotoxicity in ovarian cancer cell lines and induces fetal hemoglobin synthesis while reducing disease pathology in sickle cell mice.Related product price
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