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ChemicalBook >> CAS DataBase List >> SGC0946

SGC0946

SGC0946 price.
  • $35 - $1425
  • Product name: SGC0946
  • CAS: 1561178-17-3
  • MF: C28H40BrN7O4
  • MW: 618.57
  • EINECS:808-588-8
  • MDL Number:MFCD26523136
  • Synonyms:5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine;1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahy;SGC0946;1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea;5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-Pyrrolo[2,3-;1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5--bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydro-xytetrahydrofuran-2-yl]methyl](isopropyl)amino]pro-pyl]-3-[4-(2,2-dimethylethyl)phenyl]urea;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-;SGC0946 USP/EP/BP
Price30 Properties Safety Information Description
30 prices
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Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Apolloscientific
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 2mg
  • 2
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerAK Scientific
  • Product number2714AH
  • Product description5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • Packaging2mg
  • Price$116
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2714AH
  • Product description5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • Packaging5mg
  • Price$143
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2714AH
  • Product description5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • Packaging25mg
  • Price$446
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2714AH
  • Product description5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • Packaging50mg
  • Price$718
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA702574
  • Product description1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%
  • Packaging1mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA702574
  • Product description1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%
  • Packaging5mg
  • Price$77
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA702574
  • Product description1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%
  • Packaging10mg
  • Price$115
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA702574
  • Product description1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%
  • Packaging25mg
  • Price$194
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA702574
  • Product description1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%
  • Packaging50mg
  • Price$287
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA702574
  • Product description1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%
  • Packaging100mg
  • Price$425
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA702574
  • Product description1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%
  • Packaging250mg
  • Price$720
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4167
  • Product descriptionSGC0946
  • Packaging5mg
  • Price$99
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4167
  • Product descriptionSGC0946
  • Packaging10mg
  • Price$157
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0137
  • Product descriptionSGC0946
  • Packaging1mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0137
  • Product descriptionSGC0946
  • Packaging5mg
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0137
  • Product descriptionSGC0946
  • Packaging10mg
  • Price$174
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2714AH 5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-pyrrolo[2,3-d]pyrimidin-4-amine 2mg $116 2021-12-16 Buy
AK Scientific 2714AH 5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5mg $143 2021-12-16 Buy
AK Scientific 2714AH 5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-pyrrolo[2,3-d]pyrimidin-4-amine 25mg $446 2021-12-16 Buy
AK Scientific 2714AH 5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-pyrrolo[2,3-d]pyrimidin-4-amine 50mg $718 2021-12-16 Buy
Ambeed A702574 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+% 1mg $35 2021-12-16 Buy
Ambeed A702574 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+% 5mg $77 2021-12-16 Buy
Ambeed A702574 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+% 10mg $115 2021-12-16 Buy
Ambeed A702574 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+% 25mg $194 2021-12-16 Buy
Ambeed A702574 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+% 50mg $287 2021-12-16 Buy
Ambeed A702574 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+% 100mg $425 2021-12-16 Buy
Ambeed A702574 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+% 250mg $720 2021-12-16 Buy
ApexBio Technology A4167 SGC0946 5mg $99 2021-12-16 Buy
ApexBio Technology A4167 SGC0946 10mg $157 2021-12-16 Buy
Apolloscientific BISN0137 SGC0946 1mg $80 2021-12-16 Buy
Apolloscientific BISN0137 SGC0946 5mg $138 2021-12-16 Buy
Apolloscientific BISN0137 SGC0946 10mg $174 2021-12-16 Buy
Next Last

Properties

Melting point :125-126o C
Boiling point :771.5±60.0 °C(Predicted)
Density :1.48±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
pka :12.39±0.70(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

DOT1L is a protein methyltransferase (PMT). It is the only enzyme known to methylate histone 3 at lysine 79 (H3K79), where it catalyzes mono-, di-, and trimethylation. Proper DOT1L function is necessary for transcriptional activation of many genes, DNA damage repair, and cell cycle regulation. SGC0946 is a potent inhibitor of DOT1L (IC50 = 0.3 nM) developed by the Structural Genomics Consortium (SGC). It is over 100-fold selective over other PMTs. It is active in cells, reducing H3K79 dimethylation in A431 and MCF10A cells (IC50s = 2.6 and 8.8 nM, respectively). SGC0946 is a brominated analog of EPZ004777, an S-adenosylmethionine-competitive inhibitor of DOT1L. Both SGC0946 and EPZ004777 selectively kill mixed lineage leukemia (MLL) cells, in which DOT1L is aberrantly localized via interaction with an oncogenic MLL fusion protein.

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