VER-50589
|
- $49 - $1900
- Product name: VER-50589
- CAS: 747413-08-7
- MF: C19H17ClN2O5
- MW: 388.8
- EINECS:604-604-1
- MDL Number:MFCD18382095
- Synonyms:VER-50589;5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-Methoxyphenyl)isoxazole-3-carboxaMide;5-(5-Chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-3-isoxazolecarboxamide;VER 50589;VER50589;CS-2576;3-Isoxazolecarboxamide, 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-;VER-50589 USP/EP/BP;Apoptosis,VER-50589,HSP,VER 50589,Inhibitor,Heat shock proteins,inhibit
15 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
Package
- 500μg
- 1MG
- 5MG
- 10mg
- 100mg
- 1g
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001085
- Product description5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-3-ISOXAZOLECARBOXAMIDE 95.00%
- Packaging1MG
- Price$196.35
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001085
- Product description5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-3-ISOXAZOLECARBOXAMIDE 95.00%
- Packaging5MG
- Price$499.82
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3592
- Product descriptionVER-50589
- Packaging1mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13132
- Product descriptionVER-50589 ≥98%
- Packaging500μg
- Price$49
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13132
- Product descriptionVER-50589 ≥98%
- Packaging1mg
- Price$92
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13132
- Product descriptionVER-50589 ≥98%
- Packaging5mg
- Price$356
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM191491
- Product description5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)isoxazole-3-carboxamide 98%
- Packaging10mg
- Price$295
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2844
- Product descriptionVER-50589 99.85%
- Packaging1mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2844
- Product descriptionVER-50589 99.85%
- Packaging5mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2844
- Product descriptionVER-50589 99.85%
- Packaging10mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000889
- Product descriptionVER-50589 98+%
- Packaging5mg
- Price$189
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000889
- Product descriptionVER-50589 98+%
- Packaging10mg
- Price$315
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7737
- Product descriptionVER-50589 >98%
- Packaging100mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7737
- Product descriptionVER-50589 >98%
- Packaging1g
- Price$1900
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number49200
- Product descriptionVER-50589
- Packaging5mg
- Price$830
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | INB0001085 | 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-3-ISOXAZOLECARBOXAMIDE 95.00% | 1MG | $196.35 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001085 | 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-3-ISOXAZOLECARBOXAMIDE 95.00% | 5MG | $499.82 | 2021-12-16 | Buy |
| ApexBio Technology | B3592 | VER-50589 | 1mg | $70 | 2021-12-16 | Buy |
| Cayman Chemical | 13132 | VER-50589 ≥98% | 500μg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 13132 | VER-50589 ≥98% | 1mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 13132 | VER-50589 ≥98% | 5mg | $356 | 2024-03-01 | Buy |
| Chemenu | CM191491 | 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)isoxazole-3-carboxamide 98% | 10mg | $295 | 2021-12-16 | Buy |
| ChemScene | CS-2844 | VER-50589 99.85% | 1mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-2844 | VER-50589 99.85% | 5mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-2844 | VER-50589 99.85% | 10mg | $250 | 2021-12-16 | Buy |
| Crysdot | CD31000889 | VER-50589 98+% | 5mg | $189 | 2021-12-16 | Buy |
| Crysdot | CD31000889 | VER-50589 98+% | 10mg | $315 | 2021-12-16 | Buy |
| DC Chemicals | DC7737 | VER-50589 >98% | 100mg | $550 | 2021-12-16 | Buy |
| DC Chemicals | DC7737 | VER-50589 >98% | 1g | $1900 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 49200 | VER-50589 | 5mg | $830 | 2021-12-16 | Buy |
Properties
Boiling point :583.0±50.0 °C(Predicted)
Density :1.360±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥38.9 mg/mL in DMSO; insoluble in H2O; ≥57.2 mg/mL in EtOH
pka :7.12±0.25(Predicted)
form :solid
color :White to off-white
Density :1.360±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥38.9 mg/mL in DMSO; insoluble in H2O; ≥57.2 mg/mL in EtOH
pka :7.12±0.25(Predicted)
form :solid
color :White to off-white
Safety Information
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Description
The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-50589 is an isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM. It produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel. Consistent with inhibition of Hsp90, VER-50589 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis. VER-50589 shows favorable pharmacokinetics and impairs tumor growth in animals. Importantly, glioblastoma cells do not acquire resistance to VER-50589 and resistance to other Hsp90 inhibitors does not produce cross-resistance to VER-50589.Related product price
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