CH5138303
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- $67 - $404
- Product name: CH5138303
- CAS: 959763-06-5
- MF: C19H18ClN5O2S
- MW: 415.9
- EINECS:
- MDL Number:MFCD28099815
- Synonyms:CH5138303;Butanamide, 4-[[4-amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]-;4-[(4-Amino-6-[7-chloro-3-oxatricyclo[7.3.1.0(5,13)] trideca-1(13),5,7,9,11-pentaen-8-yl]-1,3,5-triazin-2-yl)sulfanyl]butanamide;4-[[4-Amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]butanamide;4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamid;CH5138303_Hsp90;4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-ylsulfanyl]butanamide;CH5138303 USP/EP/BP
6 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Cayman Chemical
Package
- 10mM(in 1mL DMSO)
- 1mg
- 5mg
- ManufacturerAK Scientific
- Product number2164AH
- Product description4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[DE]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamide
- Packaging1mg
- Price$228
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4571
- Product descriptionCH5138303
- Packaging1mg
- Price$67
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4571
- Product descriptionCH5138303
- Packaging5mg
- Price$237
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4571
- Product descriptionCH5138303
- Packaging10mM(in 1mL DMSO)
- Price$280
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number22417
- Product descriptionCH5138303 ≥99%
- Packaging1mg
- Price$117
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22417
- Product descriptionCH5138303 ≥99%
- Packaging5mg
- Price$404
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2164AH | 4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[DE]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamide | 1mg | $228 | 2021-12-16 | Buy |
| ApexBio Technology | B4571 | CH5138303 | 1mg | $67 | 2021-12-16 | Buy |
| ApexBio Technology | B4571 | CH5138303 | 5mg | $237 | 2021-12-16 | Buy |
| ApexBio Technology | B4571 | CH5138303 | 10mM(in 1mL DMSO) | $280 | 2021-12-16 | Buy |
| Cayman Chemical | 22417 | CH5138303 ≥99% | 1mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 22417 | CH5138303 ≥99% | 5mg | $404 | 2024-03-01 | Buy |
Properties
Boiling point :813.1±75.0 °C(Predicted)
Density :1.51±0.1 g/cm3(Predicted)
storage temp. :Desiccate at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥19.95 mg/mL in DMSO
form :solid
pka :16.39±0.40(Predicted)
color :White to off-white
Density :1.51±0.1 g/cm3(Predicted)
storage temp. :Desiccate at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥19.95 mg/mL in DMSO
form :solid
pka :16.39±0.40(Predicted)
color :White to off-white
Safety Information
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Description
CH5138303 is a triazine Hsp90 inhibitor. CH5138303 binds to the N-terminus of Hsp90α (Kd = 0.52 nM) and inhibits growth of HCT116 and NCI-N87 human tumor cell lines in vitro (IC50s = 89 and 66 nM, respectively). CH5138303 also inhibits growth of human NCI-N87 gastric cancer xenografts (ED50 = 3.9 mg/kg) and displays high oral bioavailability in mice.Related product price
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