Valrubicin
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- $45 - $2500
- Product name: Valrubicin
- CAS: 56124-62-0
- MF: C34H36F3NO13
- MW: 723.64
- EINECS:680-664-1
- MDL Number:MFCD01939322
- Synonyms:ad32 ;antibioticad32 ;nsc-246131 ;n-trifluoroacetyladriamycin-14-valerate ;n-trifluoroacetyladriamycin14-valerate ;n-trifluoroacetyldoxorubicin14-valerate ;trifluoroacetyl-adriamyci14-valerate ;trifluoroacetyladriamycin-14-valerate
24 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- AvaChem
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
- Usbiological
Package
- 500μg
- 1MG
- 5mg
- 0.01G
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- ManufacturerAK Scientific
- Product numberB954
- Product descriptionValrubicin
- Packaging25mg
- Price$525
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA191480
- Product description2-oxo-2-((2S,4S)-2,5,12-trihydroxy-4-(((2R,4S,5S,6S)-5-hydroxy-6-methyl-4-(2,2,2-trifluoroacetamido)tetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethylpentanoate 98+%
- Packaging5mg
- Price$194
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA191480
- Product description2-oxo-2-((2S,4S)-2,5,12-trihydroxy-4-(((2R,4S,5S,6S)-5-hydroxy-6-methyl-4-(2,2,2-trifluoroacetamido)tetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethylpentanoate 98+%
- Packaging10mg
- Price$291
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA191480
- Product description2-oxo-2-((2S,4S)-2,5,12-trihydroxy-4-(((2R,4S,5S,6S)-5-hydroxy-6-methyl-4-(2,2,2-trifluoroacetamido)tetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethylpentanoate 98+%
- Packaging25mg
- Price$494
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA191480
- Product description2-oxo-2-((2S,4S)-2,5,12-trihydroxy-4-(((2R,4S,5S,6S)-5-hydroxy-6-methyl-4-(2,2,2-trifluoroacetamido)tetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethylpentanoate 98+%
- Packaging50mg
- Price$642
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005346
- Product descriptionVALRUBICIN 95.00%
- Packaging0.01G
- Price$487
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005346
- Product descriptionVALRUBICIN 95.00%
- Packaging1MG
- Price$739.2
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2205
- Product descriptionValrubicin
- Packaging1mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2205
- Product descriptionValrubicin
- Packaging5mg
- Price$145
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2205
- Product descriptionValrubicin
- Packaging25mg
- Price$375
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2205
- Product descriptionValrubicin
- Packaging100mg
- Price$775
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number22964
- Product descriptionValrubicin ≥98%
- Packaging500μg
- Price$85
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22964
- Product descriptionValrubicin ≥98%
- Packaging1mg
- Price$158
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22964
- Product descriptionValrubicin ≥98%
- Packaging5mg
- Price$661
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-2929
- Product descriptionValrubicin 99.95%
- Packaging10mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2929
- Product descriptionValrubicin 99.95%
- Packaging50mg
- Price$780
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | B954 | Valrubicin | 25mg | $525 | 2021-12-16 | Buy |
| Ambeed | A191480 | 2-oxo-2-((2S,4S)-2,5,12-trihydroxy-4-(((2R,4S,5S,6S)-5-hydroxy-6-methyl-4-(2,2,2-trifluoroacetamido)tetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethylpentanoate 98+% | 5mg | $194 | 2021-12-16 | Buy |
| Ambeed | A191480 | 2-oxo-2-((2S,4S)-2,5,12-trihydroxy-4-(((2R,4S,5S,6S)-5-hydroxy-6-methyl-4-(2,2,2-trifluoroacetamido)tetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethylpentanoate 98+% | 10mg | $291 | 2021-12-16 | Buy |
| Ambeed | A191480 | 2-oxo-2-((2S,4S)-2,5,12-trihydroxy-4-(((2R,4S,5S,6S)-5-hydroxy-6-methyl-4-(2,2,2-trifluoroacetamido)tetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethylpentanoate 98+% | 25mg | $494 | 2021-12-16 | Buy |
| Ambeed | A191480 | 2-oxo-2-((2S,4S)-2,5,12-trihydroxy-4-(((2R,4S,5S,6S)-5-hydroxy-6-methyl-4-(2,2,2-trifluoroacetamido)tetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethylpentanoate 98+% | 50mg | $642 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005346 | VALRUBICIN 95.00% | 0.01G | $487 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005346 | VALRUBICIN 95.00% | 1MG | $739.2 | 2021-12-16 | Buy |
| AvaChem | 2205 | Valrubicin | 1mg | $45 | 2021-12-16 | Buy |
| AvaChem | 2205 | Valrubicin | 5mg | $145 | 2021-12-16 | Buy |
| AvaChem | 2205 | Valrubicin | 25mg | $375 | 2021-12-16 | Buy |
| AvaChem | 2205 | Valrubicin | 100mg | $775 | 2021-12-16 | Buy |
| Cayman Chemical | 22964 | Valrubicin ≥98% | 500μg | $85 | 2024-03-01 | Buy |
| Cayman Chemical | 22964 | Valrubicin ≥98% | 1mg | $158 | 2024-03-01 | Buy |
| Cayman Chemical | 22964 | Valrubicin ≥98% | 5mg | $661 | 2024-03-01 | Buy |
| ChemScene | CS-2929 | Valrubicin 99.95% | 10mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-2929 | Valrubicin 99.95% | 50mg | $780 | 2021-12-16 | Buy |
Properties
Melting point :116-117 °C
Boiling point :135-136 C
Density :1.3473 (estimate)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :7.34±0.60(Predicted)
color :Red
Water Solubility :insoluble
InChIKey :ZOCKGBMQLCSHFP-XGMQQLFPNA-N
SMILES :C12=C(O)C3=C(C(=O)C4C=CC=C(OC)C=4C3=O)C(O)=C1C[C@@](O)(C(=O)COC(=O)CCCC)C[C@@H]2O[C@@H]1O[C@H]([C@@H](O)[C@@H](NC(=O)C(F)(F)F)C1)C |&1:21,34,36,38,39,41,r|
Boiling point :135-136 C
Density :1.3473 (estimate)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :7.34±0.60(Predicted)
color :Red
Water Solubility :insoluble
InChIKey :ZOCKGBMQLCSHFP-XGMQQLFPNA-N
SMILES :C12=C(O)C3=C(C(=O)C4C=CC=C(OC)C=4C3=O)C(O)=C1C[C@@](O)(C(=O)COC(=O)CCCC)C[C@@H]2O[C@@H]1O[C@H]([C@@H](O)[C@@H](NC(=O)C(F)(F)F)C1)C |&1:21,34,36,38,39,41,r|
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||||||||||||||||||||||||||||||
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Description
Valrubicin was launched as a new 'chemotherapeutic agent for the treatment of bladder cancer, particularly in patients with BCG-refractory carcinoma in situ (CIS) of the bladder for whom immediate cystectomy is unacceptable. It belongs to the class of anthracyclines, the widest used in human cancers, and is a N-trifluoroacetyl 14-valerate derivative of doxorubicin.Valrubicin can be obtained in 3 steps from daunomycin by N-trifluoroacetylation of the sugar moiety then iodination of the 2-acetyl group and introduction of a valerate residue. A proposed mechanism involved in the cytotoxicity of Valrubicin coud be the blockade of SV40 large T antigen helicase; this cellular enzyme is involved in the formation of a ternary complex with DNA to maintain the topographic structure of DNA during transcription. In patients with CIS of bladder refractory to front line and second line therapies, intravesical instillation of Valrubicin resulted in a complete response with a significant rate and allowed a delay in cystectomy. Systemic absorption was minimal and accordingly produced a lower incidence of cardiotoxicity compared with doxorubicin.Related product price
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