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ChemicalBook >> CAS DataBase List >> YK-4-279

YK-4-279

YK-4-279 price.
  • $35 - $1853.5
  • Product name: YK-4-279
  • CAS: 1037184-44-3
  • MF: C17H13Cl2NO4
  • MW: 366.2
  • EINECS:
  • MDL Number:MFCD18382120
  • Synonyms:YK-4-279;4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one;4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one YK-4-279;YK-4-279;YK 4-279;4,7-dichloro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-indol-2-one;CS-1785;2H-Indol-2-one, 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-;YK-4-279 USP/EP/BP
Price27 Properties Safety Information Description
27 prices
Selected condition：
Brand
  • AK Scientific
  • Alichem
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Tocris
  • TRC
Package
  • 1MG
  • 5mg
  • 50mg
  • 10MG
  • 50
  • 10
  • 10mM(in 1mL DMSO)
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberSYN5754
  • Product descriptionYK-4-279
  • Packaging100mg
  • Price$567
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number1037184443
  • Product description4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one
  • Packaging250mg
  • Price$714
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number1037184443
  • Product description4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one
  • Packaging500mg
  • Price$960.4
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number1037184443
  • Product description4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one
  • Packaging1g
  • Price$1853.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008897
  • Product description4,7-DICHLORO-1,3-DIHYDRO-3-HYDROXY-3-(2-(4-METHOXYPHENYL)-2-OXOETHYL)-2H-INDOLE-2-ONE 95.00%
  • Packaging1MG
  • Price$408.4
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008897
  • Product description4,7-DICHLORO-1,3-DIHYDRO-3-HYDROXY-3-(2-(4-METHOXYPHENYL)-2-OXOETHYL)-2H-INDOLE-2-ONE 95.00%
  • Packaging10MG
  • Price$484
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3946
  • Product descriptionYK-4-279
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3946
  • Product descriptionYK-4-279
  • Packaging10mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3946
  • Product descriptionYK-4-279
  • Packaging50mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3946
  • Product descriptionYK-4-279
  • Packaging100mg
  • Price$315
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2469
  • Product descriptionYK4-279 99%
  • Packaging10mg
  • Price$104.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2469
  • Product descriptionYK4-279 99%
  • Packaging50mg
  • Price$379.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13661
  • Product descriptionYK-4-279 ≥98%
  • Packaging1mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13661
  • Product descriptionYK-4-279 ≥98%
  • Packaging5mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13661
  • Product descriptionYK-4-279 ≥98%
  • Packaging10mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13661
  • Product descriptionYK-4-279 ≥98%
  • Packaging50mg
  • Price$700
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5754 YK-4-279 100mg $567 2021-12-16 Buy
Alichem 1037184443 4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one 250mg $714 2021-12-16 Buy
Alichem 1037184443 4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one 500mg $960.4 2021-12-16 Buy
Alichem 1037184443 4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one 1g $1853.5 2021-12-16 Buy
American Custom Chemicals Corporation API0008897 4,7-DICHLORO-1,3-DIHYDRO-3-HYDROXY-3-(2-(4-METHOXYPHENYL)-2-OXOETHYL)-2H-INDOLE-2-ONE 95.00% 1MG $408.4 2021-12-16 Buy
American Custom Chemicals Corporation API0008897 4,7-DICHLORO-1,3-DIHYDRO-3-HYDROXY-3-(2-(4-METHOXYPHENYL)-2-OXOETHYL)-2H-INDOLE-2-ONE 95.00% 10MG $484 2021-12-16 Buy
ApexBio Technology A3946 YK-4-279 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology A3946 YK-4-279 10mg $70 2021-12-16 Buy
ApexBio Technology A3946 YK-4-279 50mg $210 2021-12-16 Buy
ApexBio Technology A3946 YK-4-279 100mg $315 2021-12-16 Buy
Axon Medchem Axon2469 YK4-279 99% 10mg $104.5 2021-12-16 Buy
Axon Medchem Axon2469 YK4-279 99% 50mg $379.5 2021-12-16 Buy
Cayman Chemical 13661 YK-4-279 ≥98% 1mg $35 2021-12-16 Buy
Cayman Chemical 13661 YK-4-279 ≥98% 5mg $95 2021-12-16 Buy
Cayman Chemical 13661 YK-4-279 ≥98% 10mg $160 2021-12-16 Buy
Cayman Chemical 13661 YK-4-279 ≥98% 50mg $700 2021-12-16 Buy
Next Last

Properties

Melting point :149-151℃
Boiling point :608.9±55.0 °C(Predicted)
Density :1.456
storage temp. :Store at -20° C.
solubility :insoluble in H2O; ≥16.35 mg/mL in DMSO; ≥24.25 mg/mL in EtOH with ultrasonic
form :Powder
pka :10.43±0.20(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

ES-FLI1 is an oncogenic fusion protein found in Ewing’s sarcoma, a family of undifferentiated tumors that occur throughout the body. The binding of RNA helicase A (RHA) to ES-FLI1 promotes its oncogenic function. YK-4-279 is an inhibitor of protein-protein interactions between ES-FLI1 and RHA. At 10 μM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC50 values ranging from 0.5-2 μM. At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.

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