atpenin A5
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- $125 - $571
- Product name: atpenin A5
- CAS: 119509-24-9
- MF: C15H21Cl2NO5
- MW: 366.24
- EINECS:
- MDL Number:MFCD01664873
- Synonyms:atpenin A5;(2S,4S,5R)-1-(2,4-Dihydroxy-5,6-dimethoxy-3-pyridinyl)-2,4-dimethyl-5,6-dichloro-1-hexanone;(2S,4S,5R)-5,6-Dichloro-1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2,4-dimethyl-1-hexanone;3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone;Antibiotic FO 125A5;FO 125A5;Atpenin A5 (Synthetic);2(1H)-Pyridinone, 3-[(2S,4S,5R)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-
7 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Cayman Chemical
- TRC
- Usbiological
Package
- 250ug
- 250μg
- 1mg
- 5mg
- 10mg
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0100-C250
- Product descriptionAtpeninA5 ≥95%(HPLC)
- Packaging250μg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number1618DM
- Product descriptionAtpeninA5
- Packaging1mg
- Price$571
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number11898
- Product descriptionAtpenin A5 ≥95%
- Packaging1mg
- Price$235
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberA794643
- Product descriptionAtpeninA5
- Packaging5mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberA794643
- Product descriptionAtpeninA5
- Packaging10mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number044573
- Product descriptionAtpenin A5
- Packaging250ug
- Price$368
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number169935
- Product descriptionAtpenin A5
- Packaging250ug
- Price$315
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CN2-0100-C250 | AtpeninA5 ≥95%(HPLC) | 250μg | $125 | 2021-12-16 | Buy |
| AK Scientific | 1618DM | AtpeninA5 | 1mg | $571 | 2021-12-16 | Buy |
| Cayman Chemical | 11898 | Atpenin A5 ≥95% | 1mg | $235 | 2024-03-01 | Buy |
| TRC | A794643 | AtpeninA5 | 5mg | $300 | 2021-12-16 | Buy |
| TRC | A794643 | AtpeninA5 | 10mg | $450 | 2021-12-16 | Buy |
| Usbiological | 044573 | Atpenin A5 | 250ug | $368 | 2021-12-16 | Buy |
| Usbiological | 169935 | Atpenin A5 | 250ug | $315 | 2021-12-16 | Buy |
Properties
Melting point :83-85℃
Boiling point :538.3±50.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :Chlroform (Slightly), Ethanol (Slightly), Methanol (Slightly, Sonicated)
pka :4.50±1.00(Predicted)
form :White to off-white powder.
color :White to Off-White
Boiling point :538.3±50.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :Chlroform (Slightly), Ethanol (Slightly), Methanol (Slightly, Sonicated)
pka :4.50±1.00(Predicted)
form :White to off-white powder.
color :White to Off-White
Safety Information
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| Signal word: | Danger | |||||||
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Description
Mitochondrial complex II (succinate dehydrogenase or succinate:ubiquinone oxidoreductase) is a functional member of the Krebs cycle and the aerobic respiratory chain that couples the oxidation of succinate to fumarate with the reduction of quinone to quinol. Atpenin A5, an antifungal antibiotic isolated from Penicillium sp. found in soil, is a highly specific ubiquinone-binding site inhibitor of succinate dehydrogenase (IC50s = 12 and 3.7 nM in nematode and mammalian mitochondria, respectively, versus IC50s > 100 μM for inhibition of complex I and complex III enzymes). Atpenin A5 has cardioprotective effects against simulated ischemia-reperfusion injury in cardiomyocytes. Several mechanisms through which this occurs, including activation of mitochondrial ATP-sensitive potassium channels or modulation of mitochondrial reactive oxygen species generation, have been proposed.More related product prices
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