galiellalactone
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- $219 - $1329
- Product name: galiellalactone
- CAS: 133613-71-5
- MF: C11H14O3
- MW: 194.23
- EINECS:
- MDL Number:MFCD19237657
- Synonyms:galiellalactone;SOIISBQQYAGDKM-QJSROADHSA-N;(4S,5aR,7aR,7bS)-5,5a,6,7,7a,7b-Hexahydro-7b-hydroxy-4-methylindeno[1,7-bc]furan-2(4H)-one;Indeno[1,7-bc]furan-2(4H)-one, 5,5a,6,7,7a,7b-hexahydro-7b-hydroxy-4-methyl-, (4S,5aR,7aR,7bS)-
10 prices
Selected condition:
Brand
- ApexBio Technology
- Cayman Chemical
- CSNpharm
- Tocris
- TRC
- Usbiological
Package
- 500μg
- 1mg
- 2.5mg
- 5mg
- 500U
- ManufacturerApexBio Technology
- Product numberC4650
- Product descriptionGaliellalactone
- Packaging1mg
- Price$408
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4650
- Product descriptionGaliellalactone
- Packaging2.5mg
- Price$921
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4650
- Product descriptionGaliellalactone
- Packaging5mg
- Price$1329
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15387
- Product descriptionGaliellalactone
- Packaging500μg
- Price$219
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15387
- Product descriptionGaliellalactone ≥95%
- Packaging1mg
- Price$371
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15387
- Product descriptionGaliellalactone ≥95%
- Packaging5mg
- Price$1196
- Updated2024-03-01
- Buy
- ManufacturerCSNpharm
- Product numberCSN22827
- Product descriptionGaliellalactone
- Packaging1mg
- Price$322
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number6218
- Product descriptionGaliellalactone ≥95%(HPLC)
- Packaging500U
- Price$229
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberG188953
- Product descriptionGaliellalactone
- Packaging2.5mg
- Price$660
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product numberG1044-62
- Product descriptionGaliellalactone
- Packaging1mg
- Price$523
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
ApexBio Technology | C4650 | Galiellalactone | 1mg | $408 | 2021-12-16 | Buy |
ApexBio Technology | C4650 | Galiellalactone | 2.5mg | $921 | 2021-12-16 | Buy |
ApexBio Technology | C4650 | Galiellalactone | 5mg | $1329 | 2021-12-16 | Buy |
Cayman Chemical | 15387 | Galiellalactone | 500μg | $219 | 2024-03-01 | Buy |
Cayman Chemical | 15387 | Galiellalactone ≥95% | 1mg | $371 | 2024-03-01 | Buy |
Cayman Chemical | 15387 | Galiellalactone ≥95% | 5mg | $1196 | 2024-03-01 | Buy |
CSNpharm | CSN22827 | Galiellalactone | 1mg | $322 | 2021-12-16 | Buy |
Tocris | 6218 | Galiellalactone ≥95%(HPLC) | 500U | $229 | 2021-12-16 | Buy |
TRC | G188953 | Galiellalactone | 2.5mg | $660 | 2021-12-16 | Buy |
Usbiological | G1044-62 | Galiellalactone | 1mg | $523 | 2021-12-16 | Buy |
Properties
Boiling point :400.7±38.0 °C(Predicted)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:0.97(Max Conc. mg/mL);4.99(Max Conc. mM)
Ethanol:0.97(Max Conc. mg/mL);4.99(Max Conc. mM) form :White to light tan solid.
pka :12.48±0.40(Predicted)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:0.97(Max Conc. mg/mL);4.99(Max Conc. mM)
Ethanol:0.97(Max Conc. mg/mL);4.99(Max Conc. mM) form :White to light tan solid.
pka :12.48±0.40(Predicted)
Safety Information
Symbol(GHS): |
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Signal word: | Warning | |||||||||||||||||||||
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Description
Galiellalactone is a fungal metabolite isolated from the ascomycetes G. rufa strain A75-86 and A111-95 that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells with an IC50 value of 0.25-0.5 μM. The selectivity of this compound is achieved by its ability to block the binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor. At 10-50 μM, galiellalactone exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3, suggesting it may be a useful therapeutic approach to control JAK/STAT signaling.More related product prices
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