ChemicalBook CAS DataBase List 1,1'-Biphenyl, 2,2',3,3',4,4',5,5'-octafluoro-

1,1'-Biphenyl, 2,2',3,3',4,4',5,5'-octafluoro- synthesis

7synthesis methods

Product Name:1,1'-Biphenyl, 2,2',3,3',4,4',5,5'-octafluoro-
CAS Number:5121-90-4
Molecular formula:C12H2F8
Molecular Weight:298.13

1074-91-5 Synthesis

1074-91-5
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1,1'-Biphenyl, 2,2',3,3',4,4',5,5'-octafluoro-

5121-90-4
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Yield:5121-90-4 84.7%

Reaction Conditions:

with copper in N,N-dimethyl-formamide;Inert atmosphere;Reflux;

Steps:

1.1; 2.1; 3.1; 4.1; 5.1 Step 1

Put 229 grams of 1-bromo-2.3.4.5-tetrafluorobenzene and 171.5 grams of catalyst I copper powder into DMF. The added amount of catalyst I copper powder is 1-bromo-2.3.4.5-tetrafluorobenzene The molar ratio of the added amount is 2.7:1. After refluxing under the protection of nitrogen until the reaction is complete, the remaining amount of 1-bromo-2.3.4.5-tetrafluorobenzene in the raw material is less than 1%. After cooling down, the catalyst I copper powder is removed by filtration Purification treatment: After washing with 1.5 liters of water, the organic layer was extracted with methyl tert-butyl ether: three times, 600 ml of methyl tert-butyl ether was added each time, and then dried with anhydrous magnesium sulfate. A small amount of water in butyl ether was filtered to remove magnesium sulfate, and 126.2 grams of intermediate 2,2',3,3',4,4',5,5'-octafluorobiphenyl was obtained after evaporation to dryness, with a yield of 84.7%.

References:

CN113248344,2021,A Location in patent:Paragraph 0008; 0024-0026; 0030-0032; 0036-0038; ...

551-62-2 Synthesis