![](/CAS/20180601/GIF/5121-90-4.gif)
1,1'-Biphenyl, 2,2',3,3',4,4',5,5'-octafluoro- synthesis
- Product Name:1,1'-Biphenyl, 2,2',3,3',4,4',5,5'-octafluoro-
- CAS Number:5121-90-4
- Molecular formula:C12H2F8
- Molecular Weight:298.13
![1-BROMO-2,3,4,5-TETRAFLUOROBENZENE](/CAS/GIF/1074-91-5.gif)
1074-91-5
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$42.00/1g
![1,1'-Biphenyl, 2,2',3,3',4,4',5,5'-octafluoro-](/CAS/20180601/GIF/5121-90-4.gif)
5121-90-4
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Yield:5121-90-4 84.7%
Reaction Conditions:
with copper in N,N-dimethyl-formamide;Inert atmosphere;Reflux;
Steps:
1.1; 2.1; 3.1; 4.1; 5.1 Step 1
Put 229 grams of 1-bromo-2.3.4.5-tetrafluorobenzene and 171.5 grams of catalyst I copper powder into DMF. The added amount of catalyst I copper powder is 1-bromo-2.3.4.5-tetrafluorobenzene The molar ratio of the added amount is 2.7:1. After refluxing under the protection of nitrogen until the reaction is complete, the remaining amount of 1-bromo-2.3.4.5-tetrafluorobenzene in the raw material is less than 1%. After cooling down, the catalyst I copper powder is removed by filtration Purification treatment: After washing with 1.5 liters of water, the organic layer was extracted with methyl tert-butyl ether: three times, 600 ml of methyl tert-butyl ether was added each time, and then dried with anhydrous magnesium sulfate. A small amount of water in butyl ether was filtered to remove magnesium sulfate, and 126.2 grams of intermediate 2,2',3,3',4,4',5,5'-octafluorobiphenyl was obtained after evaporation to dryness, with a yield of 84.7%.
References:
CN113248344,2021,A Location in patent:Paragraph 0008; 0024-0026; 0030-0032; 0036-0038; ...
![1,2,3,4-Tetrafluorobenzene](/CAS/GIF/551-62-2.gif)
551-62-2
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$10.00/1g
![1,1'-Biphenyl, 2,2',3,3',4,4',5,5'-octafluoro-](/CAS/20180601/GIF/5121-90-4.gif)
5121-90-4
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![1,2-Dibromotetrafluorobenzene](/CAS/GIF/827-08-7.gif)
827-08-7
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$15.00/250mg
![1,1'-Biphenyl, 2,2',3,3',4,4',5,5'-octafluoro-](/CAS/20180601/GIF/5121-90-4.gif)
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![2,3,4,5-Tetrafluorobenzoic acid](/CAS/GIF/1201-31-6.gif)
1201-31-6
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$10.00/5g
![1,1'-Biphenyl, 2,2',3,3',4,4',5,5'-octafluoro-](/CAS/20180601/GIF/5121-90-4.gif)
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1076-44-4
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![1,1'-Biphenyl, 2,2',3,3',4,4',5,5'-octafluoro-](/CAS/20180601/GIF/5121-90-4.gif)
5121-90-4
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