ChemicalBook CAS DataBase List 1,1'-Biphenyl]-2,2',6,6'-tetrol

1,1'-Biphenyl]-2,2',6,6'-tetrol synthesis

6synthesis methods

Product Name:1,1'-Biphenyl]-2,2',6,6'-tetrol
CAS Number:4371-35-1
Molecular formula:C12H10O4
Molecular Weight:218.21

19491-10-2
6 suppliers
inquiry

4371-35-1
25 suppliers
inquiry

Yield:4371-35-1 91%

Reaction Conditions:

with boron tribromide in dichloromethane at -30 - 30; for 4 h;

Steps:

2 Preparation of 2,2’,6,6’-tetrahydroxy-1,1’-biphenyl

In a 1L four neck round bottom flask, add 2 (27g), 500mL of dichloromethane successively, add boron tribromide (101g) dropwise at -30°C, and raise the resulting reaction system to 30°C for 4 hours. After the resulting reaction mixture was concentrated, 400 mL of water was added, and extraction was performed three times with ethyl acetate (600 mL each time).The residue was subjected to column chromatography to obtain 20.5 g of the target product with a yield of 91%.

References:

CN111909209,2020,A Location in patent:Paragraph 0022-0025