ChemicalBook CAS DataBase List 2,6-Dimethoxynitrobenzene 98%

2,6-Dimethoxynitrobenzene 98% synthesis

9synthesis methods

Product Name:2,6-Dimethoxynitrobenzene 98%
CAS Number:6665-97-0
Molecular formula:C8H9NO4
Molecular Weight:183.16

601-89-8 Synthesis

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77-78-1
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6665-97-0
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$60.00/100mg

Yield: 99%

Reaction Conditions:

with potassium carbonate in acetone for 1 h;Inert atmosphere;Reflux;

Steps:

2,6-Dimethoxynitrobenzene (50) (Scheme 3).
To a solution of 2-nitroresorcinol 49 (4.80 g, 30.9 mmol) in acetone (30 mL) was added K₂CO₃ (21.39 g, 155 mmol) under nitrogen atmosphere. Dimethylsulfate (8.80 mL, 92.8 mmol) was then added and the mixture obtained was heated to reflux for 1 h. After cooling to room temperature, the solvent was removed in vacuo. The solid obtained was washed with triethylamine and water, then filtered and dried (MgSO₄) to give pure compound 50⁵⁵ (5.6 g, 99%) as a white solid; TLC R_f (EtOAc) = 0.73; ¹H NMR (CDCl₃, 400 MHz) δ (ppm) 3.88 (s, 6H, 2OCH₃), 6.63 (d, J = 8.6 Hz, 2H, ArH), 7.33 (t, J = 8.6 Hz, 1H, ArH).

References:

Ghinet, Alina;Rigo, Benoît;Hénichart, Jean-Pierre;Le Broc-Ryckewaert, Delphine;Pommery, Jean;Pommery, Nicole;Thuru, Xavier;Quesnel, Bruno;Gautret, Philippe [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 20,p. 6042 - 6054] Location in patent:supporting information; experimental part

601-89-8 Synthesis

601-89-8
230 suppliers
$14.00/5g