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1,1'-Biphenyl, 4'-chloro-2,4,6-trimethyl- synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: sodium nitrite; hydrogenchloride / water / 0.5 h / 0 °C / Inert atmosphere
1.2: 0.08 h / 0 °C / Inert atmosphere
2.1: water / 0.5 h / 70 - 75 °C / Inert atmosphere

References:

Hofmann, Josefa;Gans, Eva;Clark, Timothy;Heinrich, Markus R. [Chemistry - A European Journal,2017,vol. 23,# 40,p. 9647 - 9656]