1-(1-Trityl-1H-iMidazol-4-yl)-ethanol synthesis
- Product Name:1-(1-Trityl-1H-iMidazol-4-yl)-ethanol
- CAS Number:62256-50-2
- Molecular formula:C24H22N2O
- Molecular Weight:354.44
Yield:62256-50-2 75%
Reaction Conditions:
Stage #1: methylmagnesium bromide;(1-tritylimidazol-4-yl)carboxaldehyde in tetrahydrofuran;hexane at 0 - 20;
Stage #2: with water;ammonium chloride in tetrahydrofuran;hexane;
Steps:
34
Example 34: Preparation of intermediate 8: 1-(1 -trityl-1 W-imidazol-4-yl)ethanolTo a solution of 1 -trityl-1 H-imidazole-4-carbaldehyde (10.0 g, 0.03 mol) in anhydrous THF (100 mL) was added dropwise methyl magnesium bromide (1.4 M in hexane, 52.8 mL, 0.075 mol) at O0C. After the addition, the mixture was stirred at RT overnight. The reaction was quenched with sat. aq. NH4CI (50 mL) and the mixture extracted with CH2CI2 (3*50 mL). The organic layers were combined, washed with 1 N aq. NaOH (3χ20 mL), water (3χ20 mL) and brine (100 mL), dried over MgSO4 and evaporated. The residue was purified via column chromatography {silica gel, EtOAc/Petroleum ether 1 :5) to yield the title compound (8.0 g, 75.0%) as a white solid.
References:
WO2008/4096,2008,A1 Location in patent:Page/Page column 79
33016-47-6
242 suppliers
$8.00/1g
62256-50-2
21 suppliers
inquiry
76-83-5
687 suppliers
$6.00/25g
62256-50-2
21 suppliers
inquiry
96797-15-8
239 suppliers
$21.21/250mgs:
75-07-0
417 suppliers
$14.00/5mL
62256-50-2
21 suppliers
inquiry