1-Tritylimidazole-4-carboxaldehyde synthesis
- Product Name:1-Tritylimidazole-4-carboxaldehyde
- CAS Number:33016-47-6
- Molecular formula:C23H18N2O
- Molecular Weight:338.4
Yield:33016-47-6 100%
Reaction Conditions:
with triethylamine in N,N-dimethyl-formamide at 0 - 20;
Steps:
33
Example 33: 1 -trityl-1 H-imidazole-4-carbaldehydeTo a solution of 1W-imidazole-4-carbaldehyde {30.0 g, 0.30 mol) in DMF (200 mL) was added Et3N (70 mL, 0.375 mol) under ice bath, and then Trt-CI (105 g, 0.375 mol) was added in portions and the mixture stirred at RT overnight. The mixture was evaporated in vacuo and the residue was washed with anhydrous Et2O (4 x 50 mL), and the resulting precipitate was dried to yield the title compound (100 g, 100%) as a yellow solid.
References:
PFIZER PRODUCTS INC. WO2008/4096, 2008, A1 Location in patent:Page/Page column 79
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