![](/CAS/GIF/4045-44-7.gif)
1,2,3,4,5-Pentamethylcyclopentadiene synthesis
- Product Name:1,2,3,4,5-Pentamethylcyclopentadiene
- CAS Number:4045-44-7
- Molecular formula:C10H16
- Molecular Weight:136.23
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![Methylmagnesium chloride](/CAS/GIF/676-58-4.gif)
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![1,2,3,4,5-Pentamethylcyclopentadiene](/CAS/GIF/4045-44-7.gif)
4045-44-7
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Yield:-
Reaction Conditions:
Stage #1: 2,3,4,5-tetramethyl-2-cyclopenten-1-one;methylmagnesium chloride in tetrahydrofuran at 0 - 20; for 3 h;
Stage #2: with acetic acid in tetrahydrofuran;
Stage #3: with hydrogenchloride;water in diethyl ether; for 0.5 h;
Steps:
1.A
Cyclop entadienes were synthesized starting from substituted cyclopentenones prepared according to procedure previously described in patent WO 2006051503.Cyclopentadienes were generally obtained in high molar yields (>80%) and purity (> 95%).Rn is an alkyl or alkenyl groupA solution of cyclopentenone (1 equivalents) in THF (1.6 M) was added at 00C under inert atmosphere to a solution of R11MgCl (1.2 equivalents). Reaction mixture was then allowed to warm to room temperature and stirred for 3 hours. Acetic acid 10% was then added to the reaction mixture and the organic phase was extracted with Et2O. HCl (20% in water) was added to the organic phase and allowed to stir for 30 minutes. The organic phase was then neutralized with NaHCO3 (5% in water). Washing with water, drying and evaporation of solvent gave a crude product, which was purified by distillation.
References:
WO2008/120175,2008,A1 Location in patent:Page/Page column 13
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![1,2,3,4,5-Pentamethylcyclopentadiene](/CAS/GIF/4045-44-7.gif)
4045-44-7
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$11.00/1g