1,2,3-Benzothiadiazole, 5-bromo- synthesis
- Product Name:1,2,3-Benzothiadiazole, 5-bromo-
- CAS Number:31860-01-2
- Molecular formula:C6H3BrN2S
- Molecular Weight:215.07
93933-49-4
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Yield:31860-01-2 94%
Reaction Conditions:
with sodium nitrite in water at 200; under 30003 Torr; for 0.166667 h;Temperature;Pressure;
Steps:
5-6 Example 5 Synthesis of 5-bromobenzothiadiazole
100g of 2-mercapto-5-bromoaniline and 43g of sodium nitrite aqueous solution (74wt%) were pumped to the preheating pipeline for preheating, preheated to a temperature of 200 and then sent to the continuous flow reactor, the reaction pressure through the back pressure The valve was controlled at 4 MPa, and the reaction was kept for 10 minutes. The resulting reaction liquid was allowed to stand for layering. The organic layer was collected and washed with saturated sodium chloride solution to obtain a brown-yellow liquid as the product 5-bromobenzothiadiazole, yield 94 %, purity 99.9%.
References:
CN111138380,2020,A Location in patent:Paragraph 0028-0031
20358-03-6
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