1,2:5,6-di-O-isopropylidene-D-glucitol synthesis

5synthesis methods

Product Name:1,2:5,6-di-O-isopropylidene-D-glucitol
CAS Number:53735-98-1
Molecular formula:C12H22O6
Molecular Weight:262.3

69-65-8 Synthesis

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Yield:53735-98-1 83.3%

Reaction Conditions:

with ethane;propane;tin(ll) chloride at 25; for 1.5 h;Reflux;Industrial scale;

Steps:

1 Example 1: Synthesis of GH-2

Ethane (10 L), propane (10 L), D-mannitol (10 KG, 54.9 mol), anhydrous tin dichloride (10 g, 0.05 mol) were added to the reaction vessel; the mixture was warmed to reflux and the reaction mixture was allowed to stand for 1 hour. Clarify, continue to react for 0.5 hours; cool down to 25 °C, add pyridine (13ml), acetic anhydride (7ml), stir for 10 minutes; remove the solvent under reduced pressure, the internal temperature is controlled below 70 °C; GH-2 after evaporation to dryness , 12kg, yield 83.3%.

References:

CN107857787,2018,A Location in patent:Paragraph 0008; 0013

50-70-4 Synthesis