1-(2-Chloroethoxy)-4-nitrobenzene synthesis
- Product Name:1-(2-Chloroethoxy)-4-nitrobenzene
- CAS Number:3383-72-0
- Molecular formula:C8H8ClNO3
- Molecular Weight:201.61
Yield: 84%
Reaction Conditions:
with potassium carbonate in acetonitrile at 80;
Steps:
2a Preparation Example 2a: 1-(2-Chloroethoxy)-4-nitrobenzene
p-Nitrophenol (1.39 g, 10 mmol) and potassium carbonate (1.38 g, 10 mmol) were added to 25 ml of acetonitrile, and then 1-bromo-2-chloroethane (2.5 ml, 30 mmol) was added dropwise, and the mixture was refluxed at 80 ° C overnight. After the reaction, water was added to dissolve potassium carbonate, extracted with ethyl acetate, and the organic phase was washed with saturated sodium hydrogencarbonate and brine.Evaporation to dryness gave a white solid (1.69 g, yield 84%).The product was not purified.Used directly in the next step.
References:
Beijing Xinchen Pharmaceutical Technology Co., Ltd.;Yin Yuxin;Zhai Zheng CN109593064, 2019, A Location in patent:Paragraph 0089; 0090; 0091
16365-27-8
71 suppliers
$33.39/1g
3383-72-0
143 suppliers
$25.00/1g
100-02-7
19 suppliers
$11.00/5G
3383-72-0
143 suppliers
$25.00/1g
100-02-7
19 suppliers
$11.00/5G
16670-48-7
44 suppliers
$45.00/50mg
3383-72-0
143 suppliers
$25.00/1g
16365-27-8
71 suppliers
$33.39/1g
144-55-8
1323 suppliers
$10.00/25g
3383-72-0
143 suppliers
$25.00/1g