ChemicalBook CAS DataBase List 1-(2-Chloroethoxy)-4-nitrobenzene

1-(2-Chloroethoxy)-4-nitrobenzene synthesis

10synthesis methods

Product Name:1-(2-Chloroethoxy)-4-nitrobenzene
CAS Number:3383-72-0
Molecular formula:C8H8ClNO3
Molecular Weight:201.61

100-02-7 Synthesis

100-02-7
5 suppliers
$11.00/5G

107-04-0
272 suppliers
$9.00/1g

3383-72-0
142 suppliers
$25.00/1g

Yield: 84%

Reaction Conditions:

with potassium carbonate in acetonitrile at 80;

Steps:

2a Preparation Example 2a: 1-(2-Chloroethoxy)-4-nitrobenzene
p-Nitrophenol (1.39 g, 10 mmol) and potassium carbonate (1.38 g, 10 mmol) were added to 25 ml of acetonitrile, and then 1-bromo-2-chloroethane (2.5 ml, 30 mmol) was added dropwise, and the mixture was refluxed at 80 ° C overnight. After the reaction, water was added to dissolve potassium carbonate, extracted with ethyl acetate, and the organic phase was washed with saturated sodium hydrogencarbonate and brine.Evaporation to dryness gave a white solid (1.69 g, yield 84%).The product was not purified.Used directly in the next step.

References:

Beijing Xinchen Pharmaceutical Technology Co., Ltd.;Yin Yuxin;Zhai Zheng CN109593064, 2019, A Location in patent:Paragraph 0089; 0090; 0091