1-(2-Fluoro-3-hydroxyphenyl)ethanone synthesis
- Product Name:1-(2-Fluoro-3-hydroxyphenyl)ethanone
- CAS Number:1191999-09-3
- Molecular formula:C8H7FO2
- Molecular Weight:154.14
208777-19-9
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1191999-09-3
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Yield:-
Reaction Conditions:
Stage #1: 1-(2-fluoro-3-methoxyphenyl)ethan-1-onewith aluminum (III) chloride in chlorobenzene at 130; for 1.5 h;
Stage #2: with water in chlorobenzene;
Steps:
53.iii
To a solution of Compound III (365 mg) in chlorobenzene (7.2 mL) was added aluminium chloride (724 mg), and the mixture was stirred at 130° C. for 1.5 hour. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, and concentrated under reduced pressure to give Compound IV (300 mg) as a crude product.
References:
US2012/225876,2012,A1 Location in patent:Page/Page column 55
137654-20-7
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1191999-09-3
34 suppliers
$145.00/1g
693220-47-2
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1191999-09-3
34 suppliers
$145.00/1g