ChemicalBook CAS DataBase List 1-(2-Hydroxyethyl)cyclopentanol

1-(2-Hydroxyethyl)cyclopentanol synthesis

8synthesis methods

Product Name:1-(2-Hydroxyethyl)cyclopentanol
CAS Number:73089-93-7
Molecular formula:C7H14O2
Molecular Weight:130.18

Cyclopentaneacetic acid, 1-hydroxy-, 1,1-dimethylethyl ester

13278-09-6
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73089-93-7
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Yield:73089-93-7 100%

Reaction Conditions:

with lithium aluminium tetrahydride in tetrahydrofuran at 0 - 20;

Steps:

43.2 Step 2 l -(2-hydroxyethyl)cyclopentanol

Step 2 l -(2-hydroxyethyl)cyclopentanol To a solution of tert-butyl 2-(l-hydroxycyclopentyl)acetate (0.5 g, 2.5 mmol) in THF (10 mL) was added lithium aluminium hydride (0.28 g, 7.5 mmol) portionwise at 0°C. The reaction was stirred at room temperature overnight. The mixture was partitioned between ethyl acetate and water. The combined organic layer was dried over sodium sulfate, filtered and concentrated to give a crude product which was purified by column chromatography eluting with petroleum ether/ ethyl acetate (1 : 1) to give l-(2-hydroxyethyl)cyclopentanol (0.33 g, 100%) as a yellow oil.

References:

WO2014/143799,2014,A2 Location in patent:Page/Page column 401; 402

110-52-1 Synthesis