![](/CAS/GIF/948570-75-0.gif)
1-(2-Methoxyethyl)-4-nitro-1H-pyrazole synthesis
- Product Name:1-(2-Methoxyethyl)-4-nitro-1H-pyrazole
- CAS Number:948570-75-0
- Molecular formula:C6H9N3O3
- Molecular Weight:171.15
![4-Nitropyrazole](/CAS/GIF/2075-46-9.gif)
2075-46-9
309 suppliers
$6.00/5g
![1-Bromo-2-methoxyethane](/CAS/GIF/6482-24-2.gif)
6482-24-2
282 suppliers
$9.00/1g
![1-(2-Methoxyethyl)-4-nitro-1H-pyrazole](/CAS/GIF/948570-75-0.gif)
948570-75-0
35 suppliers
$23.00/250mg
Yield:948570-75-0 100%
Reaction Conditions:
with potassium carbonate in acetonitrile at 80; for 4 h;
Steps:
39 Synthesis ofl-(2-methoxyethyl)-4-nitro-1H-pyrazole
[0223j To a mixture of 4-nitro-1H-pyrazole (113 mg, 1 mmol, 1.0 eq) in CH3CN (5 mL), 1-bromo-2-methoxyethane (138 mg, 1 mmol, 1.0 equiv) and K2C03 (276 mg, 2 mmol, 2.0 equiv) was added. The mixture was stirred at 80 °C for 4 h. After diluted with EtOAc (100 mL), the mixture was washed with water (50 mL x 2). The organic layer was concentrated and purified by silica gel column (petroleum ether/EtOAc = 10 : 1) to give 1-(2-methoxyethyl)-4-nitro-1H- pyrazole (170 mg, yield: 100%) as a colorless oil. ESI-MS (M+H): 172.1. ‘H NMR (400 MHz, CDC13) (5: 8.23 (s, 1H), 8.07 (s, 1H), 4.31 (t, J= 5.2 Hz, 2H), 3.74 (t, J= 5.2 Hz, 2H), 3.35 (s, 3H).
References:
WO2015/89337,2015,A1 Location in patent:Paragraph 0223
![4-Nitropyrazole](/CAS/GIF/2075-46-9.gif)
2075-46-9
309 suppliers
$6.00/5g
![2-Methoxyethanol](/CAS/GIF/109-86-4.gif)
109-86-4
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$11.00/25g
![1-(2-Methoxyethyl)-4-nitro-1H-pyrazole](/CAS/GIF/948570-75-0.gif)
948570-75-0
35 suppliers
$23.00/250mg
![1-hydroxyethyl-4-nitropyrazole](/CAS/GIF/42027-81-6.gif)
42027-81-6
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$53.00/250mg
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
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$15.00/10g
![1-(2-Methoxyethyl)-4-nitro-1H-pyrazole](/CAS/GIF/948570-75-0.gif)
948570-75-0
35 suppliers
$23.00/250mg
![4-Nitropyrazole](/CAS/GIF/2075-46-9.gif)
2075-46-9
309 suppliers
$6.00/5g
![2-Methoxyethyl chloride](/CAS/GIF/627-42-9.gif)
627-42-9
269 suppliers
$6.00/5g
![1-(2-Methoxyethyl)-4-nitro-1H-pyrazole](/CAS/GIF/948570-75-0.gif)
948570-75-0
35 suppliers
$23.00/250mg