1-(3,4-Dihydroxyphenyl)butan-1-one synthesis

4synthesis methods

Product Name:1-(3,4-Dihydroxyphenyl)butan-1-one
CAS Number:17386-89-9
Molecular formula:C10H12O3
Molecular Weight:180.2

120-80-9 Synthesis

120-80-9
501 suppliers
$13.00/25g

141-75-3
337 suppliers
$12.32/25G

17386-89-9
11 suppliers
$87.00/100mg

Yield:17386-89-9 82%

Reaction Conditions:

with aluminum (III) chloride in 1,2-dichloro-ethane at 0 - 20; for 24 h;Friedel-Crafts Acylation;

Steps:

Acylation of pyrocatechol; General Procedure

General procedure: The appropriate acyl chloride (0.45 mol) was added dropwise to a stirred suspension of pyrocatechol (33 g, 0.3 mol) and aluminum chloride (120 g, 0.9 mol) in 1,2-dichloroethane (500 mL) on an ice bath during 1 h. The reaction mixture was stirred in an ice bath for 3 hours, then warmed to room temperature, stirred 20 h, quenched with cold dilute hydrochloric acid solution (5%, 1 L). The precipitate was filtered off, washed with water and dried. The organic layer was separated, washed with water, dried (Na₂SO₄) and evaporated. The aqueous layer was extracted with ethyl acetate (3 x 300 mL). An ethyl acetate solution was washed with water, dried (Na₂SO₄) and evaporated. The residues were combined with the precipitate and used in the next step without further purification. A small amount of the substance was purified by flash chromatography (silica gel, hexane/acetone, 5:1) for analytical purposes.

References:

Khmelevskaya, Ekaterina A.;Pelageev, Dmitry N. [Tetrahedron Letters,2019,vol. 60,# 15,p. 1022 - 1024] Location in patent:supporting information

120-80-9 Synthesis

120-80-9
501 suppliers
$13.00/25g

107-92-6 Synthesis