1,3,5-Tris(2-hydroxyethyl)cyanuric acid synthesis

Yield:839-90-7 271.6 g

Reaction Conditions:

with triethylamine in N,N-dimethyl-formamide at 80 - 85;Reagent/catalyst;Temperature;Solvent;

Steps:

1-3; 1-4

S1: Mix cyanuric acid (129g, 1mol) and TEA (5mol) in DMF (900mL) uniformly, heat to 80°C, add chloroethanol (6mol) dropwise to the reaction system, control the temperature of the system during the dropping process < At 85°C, after the dropwise addition is completed, the reaction is kept at 80°C. After the reaction is completed, the temperature is lowered and the solvent is removed under reduced pressure to obtain the crude product.S2: Add the crude SEC to methanol (520mL) with 20% water content, heat to reflux, keep for 20min, cool to 25 naturally, cool to 0 in an ice bath, crystallize for 6h, then filter, the water content is 5 It was washed with% methanol and dried to obtain 271.6g. The HPLC purity of Sec was 76.3.2%.

References:

CN112300089,2021,A Location in patent:Paragraph 0041-0067