1-(3-CARBOXYPROPYL)3,7-DIMETHYL XANTHINE synthesis
- Product Name:1-(3-CARBOXYPROPYL)3,7-DIMETHYL XANTHINE
- CAS Number:6493-07-8
- Molecular formula:C11H14N4O4
- Molecular Weight:266.25
83636-88-8
10 suppliers
inquiry
6493-07-8
37 suppliers
$176.00/50mg
Yield:6493-07-8 66%
Reaction Conditions:
with water;potassium hydroxide in acetone; for 30 h;Reflux;
Steps:
A General Procedure for Preparing -(3,7-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)alkylcarboxlicAcids (17, 18)
General procedure: Mixture of 1 eq. (10 mmol) of appropriate ethyl -(3,7-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)alkylcarboxlate(1, 2) and 2 eq. of KOH in acetone/water mixture(50 ml, 1:2, v/v) was refluxed for 30 h. Afterwards the reactionmixture was evaporated under reduced pressure and theresidue was dissolved in a small amount of water (ca. 10 ml).Solution was acidified with conc. HCl to pH ca. 3, cooledand a precipitate of product was filtered off. Products werecrystallized from water.
References:
Zygmunt, Maigorzata;Zmudzki, Pawe?;Ch?oń-Rzepa, Grazyna;Sapa, Jacek;Paw?owski, Maciej [Letters in drug design and discovery,2014,vol. 11,# 10,p. 1204 - 1213]
83-67-0
455 suppliers
$5.00/100mg
6493-07-8
37 suppliers
$176.00/50mg
6493-05-6
260 suppliers
$6.00/100mg
6493-07-8
37 suppliers
$176.00/50mg