ChemicalBook CAS DataBase List 1-(3-Nitorpyridin-2-yl)piperazine

1-(3-Nitorpyridin-2-yl)piperazine synthesis

6synthesis methods

Product Name:1-(3-Nitorpyridin-2-yl)piperazine
CAS Number:87394-48-7
Molecular formula:C9H12N4O2
Molecular Weight:208.22

110-85-0 Synthesis

110-85-0
550 suppliers
$5.00/5G

5470-18-8
433 suppliers
$6.00/5g

87394-48-7
68 suppliers
$14.00/100mg

Yield:87394-48-7 95%

Reaction Conditions:

in acetonitrile;Heating / reflux;

Steps:

17.1

Example 17.1: 1 -(3-Nitro-pyridin-2-yl)-piperazine. A mixture of 2-chloro-3-nitro-pyridine (2,0 g, 0.013 mol), piperazine (5.43 g, 0.063 mol) and acetonitrile (50 mL) was heated at reflux overnight. The reaction mixture was cooled to room temperature, diluted with ethyl acetate, washed with water and washed with brine. The organic layer was separated, dried over sodium sulfate, filtered and concentrated to give l-(3-nitro-pyridin-2-yl)-piperazine (2.5 g, 95 %). The product was used without further purification.

References:

WO2008/112440,2008,A1 Location in patent:Page/Page column 38

5470-18-8
433 suppliers
$6.00/5g

142-64-3 Synthesis