1,3-THIAZOLE-4-CARBONYL CHLORIDE synthesis

1synthesis methods

Product Name:1,3-THIAZOLE-4-CARBONYL CHLORIDE
CAS Number:3745-79-7
Molecular formula:C4H2ClNOS
Molecular Weight:147.58

3973-08-8 Synthesis

3973-08-8
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$6.00/1g

3745-79-7
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$45.00/50mg

Yield:3745-79-7 99%

Reaction Conditions:

with dichlorosulfoxide for 2 h;Heating / reflux;

Steps:

96A

Preparation 96A; Thiazole-4-carbonyl chlorideA mixture of thiazole-4-carboxylic acid (30.0 g, 232 mmol) and thionyl chloride (200 ml.) was heated at reflux for 2h. The resulting solution was evaporated and the residue dried giving a yellow solid. Yield 34.0 g, 99%. ¹H NMR (CDCI₃) δ 8.91 (d, 1H, J = 2 Hz)₁ 8.49 (d, 1H, J = 2 Hz).

References:

WO2008/4117,2008,A1 Location in patent:Page/Page column 161

1,3-THIAZOLE-4-CARBONYL CHLORIDE Related Search:

2-(2-THIENYL)-1,3-THIAZOLE-4-CARBONYL CHLORIDE 2-(2,6-DICHLOROBENZYL)-1,3-THIAZOLE-4-CARBONYL CHLORIDE 2-PHENYL-1,3-THIAZOLE-4-CARBONYL CHLORIDE 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBONYL CHLORIDE 5-Thiazolecarbonyl chloride, 2-chloro- (9CI) 4-Thiazolecarbonyl chloride, 2-methyl- (9CI)