1-(4-Bromophenyl)-naphthlene synthesis

Yield:204530-94-9 81%

Reaction Conditions:

with sodium carbonate;tetrakis(triphenylphosphine) palladium⁽⁰⁾ in water;toluene at 90; for 24 h;Inert atmosphere;

Steps:

4.1 [Synthesis Reference 4-1] Synthesis of 1-(4-bromophenyl)naphthalene
Under an argon gas atmosphere, 200.0 g (1.163 mol) of 1-naphthaleneboronic acid, 329.0 g (1.163 mol) of 4-bromoiodobenzene, 26.9 g (23.3 mmol) of tetrakis(triphenylphosphine)palladium(0), 3.7 L of toluene and 1.74 L of aqueous solution of 2M sodium carbonate were added together, and stirred at 90 degrees C. for 24 hours. After the reaction was over, the mixture experienced filtration, through which aqueous phase thereof was eliminated. The organic phase thereof was washed by water and dried with magnesium sulfate, and the toluene was then distilled away under reduced pressure. Residue thereof was refined by silica-gel column chromatography, such that 268 g of 1-(4-bromophenyl) naphthalene was obtained at an yield of 81%.

References:

Idemitsu Kosan Co., Ltd. US2010/331585, 2010, A1 Location in patent:Page/Page column 96

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