ChemicalBook CAS DataBase List 1,4-Diphenoxybenzene

1,4-Diphenoxybenzene synthesis

12synthesis methods

Product Name:1,4-Diphenoxybenzene
CAS Number:3061-36-7
Molecular formula:C18H14O2
Molecular Weight:262.3

108-86-1 Synthesis

108-86-1
497 suppliers
$10.00/5g

831-82-3 Synthesis

831-82-3
304 suppliers
$5.00/5g

3061-36-7
139 suppliers
$30.30/5g

Yield:-

Reaction Conditions:

Stage #1:4-Phenoxyphenol with potassium hydroxide in water;N,N-dimethyl-formamide;tolueneInert atmosphere;azeotropic removal of the water;
Stage #2:bromobenzene with copper(II) oxide in N,N-dimethyl-formamide at 153; for 24 h;

Steps:

1
4-Phenoxyphenol (186.2 g, 1.0 mol) is dissolved in 1600 g of DMF with 300 mL toluene under nitrogen. A 50% KOH solution (112.0 g, 1.0 mol) is added followed by azeo tropic removal of the water and stripping of the toluene. Bromobenzene (157.0 g, 1.0 mol) and cupric oxide (3.2 g, 0.04 mol) are then added and the reaction solution held at reflux (153 °C) for 24 hr. The DMF is then removed by stripping and the residue worked up to give 1,4- diphenoxybenzene.

References:

CHEMTURA CORPORATION;TIMBERLAKE, Larry, D WO2011/90631, 2011, A1 Location in patent:Page/Page column 12

624-38-4 Synthesis