1-(4-FLUORO-BENZYL)-1H-PYRAZOL-3-YLAMINE synthesis
- Product Name:1-(4-FLUORO-BENZYL)-1H-PYRAZOL-3-YLAMINE
- CAS Number:492426-35-4
- Molecular formula:C10H10FN3
- Molecular Weight:191.2
1820-80-0
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$5.00/5g
459-46-1
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$10.00/1g
492426-35-4
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$45.00/50mg
Yield:492426-35-4 57%
Reaction Conditions:
with potassium carbonate in acetonitrile at 50; for 8 h;
Steps:
10.A
A suspension of 3-aminopyrazole (0.94 g, 11.30 mmol) and compound 10-4 (2.35 g, 12.45 mmol) in acetonitrile (50 mL) was treated with potassium carbonate (3.91 g, 28.28 mmol), and then the mixture was heated To 50°C, and keep at this temperature for 8h. The mixture was cooled to 25°C, and the insoluble matter was filtered off. The supernatant was concentrated and purified by column chromatography (0% to 50% methanol/dichloromethane) to obtain pure product 8-7 (1.23g, 57%)
References:
CN113493442,2021,A Location in patent:Paragraph 0227-0230