ChemicalBook CAS DataBase List 3-Aminopyrazole

3-Aminopyrazole synthesis

3synthesis methods

Product Name:3-Aminopyrazole
CAS Number:1820-80-0
Molecular formula:C3H5N3
Molecular Weight:83.09

The synthesis of 3-Aminopyrazole is as follows:A solution of 50 mg (0.34 mmol) of 3-oxo-3-phenylpropanenitrile and 11.6 mg (0.36 mmol) of hydrazine and 0.024 mL of acetic acid (0.37 mmol) in 3 mL of anhydrous ethanol was heated at 60° C for 24 hr. The mixture was cooled to ambient temperature and the solvent removed in vacuo. The residue was taken up in ethyl acetate, washed with saturated sodium bicarbonate. The organic layer was washed with brine and dried over MgSO4, filtered and evaporated. The solid residue waswashedwithethyl ether and dried in vacuo to give 45 mg (82%) of 3-phenyl-1H-pyrazol-5-amine.

6162-76-1 Synthesis

6162-76-1
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1820-80-0
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Yield:-

Reaction Conditions:

with hydrazine in ethanol at 60; for 24 h;

Steps:

Step ii:

General procedure: A solution of 50 mg (0.34 mmol) of 3-oxo-3-phenylpropanenitrile and 11.6 mg (0.36 mmol) of hydrazine and 0.024 mL of acetic acid (0.37 mmol) in 3 mL of anhydrous ethanol was heated at 60° C for 24 hr. The mixture was cooled to ambient temperature and the solvent removed in vacuo. The residue was taken up in ethyl acetate, washed with saturated sodium bicarbonate. The organic layer was washed with brine and dried over MgSO₄, filtered and evaporated. The solid residue waswashedwithethyl ether and dried in vacuo to give 45 mg (82%) of 3-phenyl-1H-pyrazol-5-amine.

References:

Rana, Sandeep;Sonawane, Yogesh A.;Taylor, Margaret A.;Kizhake, Smitha;Zahid, Muhammad;Natarajan, Amarnath [Bioorganic and Medicinal Chemistry Letters,2018,vol. 28,# 23-24,p. 3736 - 3740] Location in patent:supporting information

26621-44-3 Synthesis

26621-44-3
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1820-80-0
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References

41680-34-6 Synthesis

41680-34-6
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1820-80-0
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References

3-Aminopyrazole Related Search:

Triethanolamine Dibenzylamine Bis(2-ethylhexyl)amine 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Aminopyrazine Triallylamine Triethylamine Metazachlor Pyraclostrobin Zolpidem