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ChemicalBook CAS DataBase List Triethylamine
121-44-8

Triethylamine synthesis

11synthesis methods

Triethylamine is a colourless volatile liquid with a strong fishy odor reminiscent of ammonia. Triethylamine is synthesised by the alkylation of ammonia with ethanol.

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Yield:121-44-8 80%

Reaction Conditions:

in dichloromethane

Steps:

6-n-propyl-2-formyl-8beta-ergoline-carboxylic acid methyl ester
The aldehyde is obtained from the corresponding Mannich base by oxidation with trichloroisocyanuric acid in dichloromethane and triethylamine at -78° C. in approximately 80% yield.

References:

Schering Aktiengesellschaft US5219862, 1993, A

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