1-(4-FLUORO-PHENYL)-PYRROLE-2,5-DIONE synthesis
- Product Name:1-(4-FLUORO-PHENYL)-PYRROLE-2,5-DIONE
- CAS Number:6633-22-3
- Molecular formula:C10H6FNO2
- Molecular Weight:191.16
108-31-6
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371-40-4
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6633-22-3
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Yield:6633-22-3 95.5%
Reaction Conditions:
with sodium acetate;acetic acid at 20 - 85; for 6 h;
Steps:
Synthesis
HL was prepared by the two-steps process (Scheme 1). At first N-(4-fluorophenyl)maleimide was obtained in the following way. A mixture of 11.1 g (0.1 mol) of 4-fluoroaniline with 10.0 g (0.105 mol) of maleic anhydride, 8.2 g sodium acetate, and 50 mL acetic acid was stirred over 1 h at room temperature. Then the mixture was heated at 80-85C for 5 h. Upon following cooling down the flask content was poured onto ice. The colourless precipitate was filtered off and washed with water. Yield 18.3 g(95.5%), mp 147.5C [20].
References:
Ferenc;Sadowski;Tarasiuk;Cristóv?o;Osypiuk;Sarzyński [Russian Journal of General Chemistry,2017,vol. 87,# 11,p. 2719 - 2727][Zh. Obshch. Khim.,2017,vol. 87,# 11,p. 2719 - 2727,9]
780-05-2
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inquiry
6633-22-3
59 suppliers
$69.00/200mg
371-40-4
404 suppliers
$5.00/5G
6633-22-3
59 suppliers
$69.00/200mg
108-31-6
839 suppliers
$13.47/50g
52326-08-6
1 suppliers
inquiry
6633-22-3
59 suppliers
$69.00/200mg