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1-(4-Fluorophenyl)-2-(trifluoromethyl)-1H-indole synthesis

2synthesis methods
Benzene, 1-bromo-2-(2-chloro-3,3,3-trifluoro-1-propen-1-yl)-

1188436-17-0
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371-40-4 Synthesis
4-Fluoroaniline

371-40-4
405 suppliers
$5.00/5G

1-(4-Fluorophenyl)-2-(trifluoromethyl)-1H-indole

1233881-86-1
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Yield:1233881-86-1 87%

Reaction Conditions:

with tris-(dibenzylideneacetone)dipalladium(0);sodium t-butanolate;DavePhos in toluene at 140; for 14 h;Inert atmosphere;

References:

Dong, Shu-Xiang;Zhang, Xing-Guo;Liu, Qiong;Tang, Ri-Yuan;Zhong, Ping;Li, Jin-Heng [Synthesis,2010,# 9,art. no. F24509SS,p. 1521 - 1525] Location in patent:experimental part