1-(4-Fluorophenyl)piperazin-2-one hydrochloride synthesis

5synthesis methods

Product Name:1-(4-Fluorophenyl)piperazin-2-one hydrochloride
CAS Number:697305-48-9
Molecular formula:C10H12ClFN2O
Molecular Weight:230.6665

1284243-44-2 Synthesis

tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate

1284243-44-2
27 suppliers
$29.00/100mg

1-(4-Fluorophenyl)piperazin-2-one hydrochloride

697305-48-9
19 suppliers
$183.59/250mg

Yield:697305-48-9 100%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane at 20;

Steps:

16.A

Hydrogen chloride (4 N in 1 ,4-dioxane) (4 mL, 32 mmol) was added and the mixture was stirred at room temperature for several hours. The solvent was evaporated to give the title compound (0.135 g, quantitative) as a white solid. ¹H NMR (400 MHz, DMSO-Qf₆) δ ppm 9.79 (br. s., 1 H) 7.34 - 7.41 (m, 2 H) 7.25 - 7.34 (m, 2 H) 3.82 - 3.92 (m, 4 H) 3.53 (d, 2 H).

References:

WO2011/41713,2011,A2 Location in patent:Page/Page column 152