ChemicalBook CAS DataBase List 1-(4-METHOXY-PHENYL)-2-METHYLAMINO-ETHANOL

1-(4-METHOXY-PHENYL)-2-METHYLAMINO-ETHANOL synthesis

7synthesis methods

Product Name:1-(4-METHOXY-PHENYL)-2-METHYLAMINO-ETHANOL
CAS Number:58777-87-0
Molecular formula:C10H15NO2
Molecular Weight:181.23

Oxazolidine, 5-(4-methoxyphenyl)-3-methyl-

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1-(4-METHOXY-PHENYL)-2-METHYLAMINO-ETHANOL

58777-87-0
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Yield:-

Reaction Conditions:

with hydrazine hydrate in ethanol at 20; for 45 h;Reflux;

Steps:

For the preparation of amino alcohols 1b,c,h,i

General procedure: the corresponding oily oxazolidine2 was dissolved in EtOH (1 mL) and treated with hydrazine hydrate (0.4 mL).The resulting mixture was left at room temperature for 2 d and then refluxedfor 3 h. The solvents were evaporated in vacuo and a concentrated aqueoussolution of NaOH was added to the residue. Extraction with CH2Cl2 (2 2 mL),drying over Na2SO4, and evaporation gave the crude 1-aryl-2-(methylamino)ethanol, which was recrystallized from CH2Cl2-heptane mixture

References:

Moshkin, Vladimir S.;Sosnovskikh, Vyacheslav Ya. [Tetrahedron Letters,2013,vol. 54,# 44,p. 5869 - 5872]

123-11-5 Synthesis