![](/CAS/GIF/87394-65-8.gif)
1-(5-CHLORO-PYRIDIN-2-YL)-PIPERAZINE synthesis
- Product Name:1-(5-CHLORO-PYRIDIN-2-YL)-PIPERAZINE
- CAS Number:87394-65-8
- Molecular formula:C9H12ClN3
- Molecular Weight:197.66
![TERT-BUTYL 4-(5-CHLOROPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE](/CAS/20200119/GIF/945422-86-6.gif)
945422-86-6
7 suppliers
$904.00/5g
![1-(5-CHLORO-PYRIDIN-2-YL)-PIPERAZINE](/CAS/GIF/87394-65-8.gif)
87394-65-8
74 suppliers
$21.00/250mg
Yield:87394-65-8 99%
Reaction Conditions:
Stage #1: tert-butyl 4-(5-chloropyridin-2-yl)piperazine-1-carboxylatewith trifluoroacetic acid in MC at 20; for 2 h;
Stage #2: with sodium hydrogencarbonate in water;
Steps:
85.2
Step 2: Synthesis of 1-(5-Chloropyridin-2-yl)piperazine [255] Tert-butyl 4-(5-chloropyridin-2-yl)piperazine-1-carboxylate (170 mg, 0.571 mmol) was dissolved in MC (3 ml), followed by addition of trifluoroacetic acid (3 ml), and then the resulting mixture was stirred at room temperature for 2 hours. The resulting reaction liquid was concentrated under reduced pressure, followed by addition of a saturated aqueous NaHCO3 solution (15 ml), and extracted with MC (15 ml x 3). The organic layer was dried over anhydrous sodium sulfate, followed by filtration, concentration, and vacuum drying, to obtain 112 mg of white solid (99%).
References:
WO2011/139107,2011,A2 Location in patent:Page/Page column 39
![Piperazine](/CAS/GIF/110-85-0.gif)
110-85-0
549 suppliers
$5.00/5G
![2,5-Dichloropyridine](/CAS/GIF/16110-09-1.gif)
16110-09-1
453 suppliers
$5.00/1g
![1-(5-CHLORO-PYRIDIN-2-YL)-PIPERAZINE](/CAS/GIF/87394-65-8.gif)
87394-65-8
74 suppliers
$21.00/250mg
![Piperazine](/CAS/GIF/110-85-0.gif)
110-85-0
549 suppliers
$5.00/5G
![2-Bromo-5-chloropyridine](/CAS/GIF/40473-01-6.gif)
40473-01-6
418 suppliers
$5.00/1g
![1-(5-CHLORO-PYRIDIN-2-YL)-PIPERAZINE](/CAS/GIF/87394-65-8.gif)
87394-65-8
74 suppliers
$21.00/250mg
![2-Bromo-5-chloropyridine](/CAS/GIF/40473-01-6.gif)
40473-01-6
418 suppliers
$5.00/1g
![1-(5-CHLORO-PYRIDIN-2-YL)-PIPERAZINE](/CAS/GIF/87394-65-8.gif)
87394-65-8
74 suppliers
$21.00/250mg