ChemicalBook CAS DataBase List 1-(6-CHLORO-PYRIDIN-2-YL)-PIPERAZINE

1-(6-CHLORO-PYRIDIN-2-YL)-PIPERAZINE synthesis

6synthesis methods

Product Name:1-(6-CHLORO-PYRIDIN-2-YL)-PIPERAZINE
CAS Number:87394-54-5
Molecular formula:C9H12ClN3
Molecular Weight:197.66

110-85-0 Synthesis

110-85-0
551 suppliers
$5.00/5G

2402-78-0 Synthesis

2402-78-0
512 suppliers
$6.00/25g

584-08-7 Synthesis

584-08-7
1180 suppliers
$5.00/100g

87394-54-5
46 suppliers
$60.00/50mg

Yield:87394-54-5 90%

Reaction Conditions:

in water;acetonitrile;

Steps:

4 1-(6-Chloro-2-pyridinyl)piperazine

EXAMPLE 4 1-(6-Chloro-2-pyridinyl)piperazine A mixture of 2.6-dichloropyridine (4.0 g), anhydrous piperazine (6.97 g), and micropulverized anhydrous K₂ CO₃ (7.45 g) in acetonitrile (50 ml) was heated at reflux with stirring while under N₂ atmosphere for 20 h. The excess acetonitrile was removed under reduced pressure and water (15 mL) added to the concentrate. The aqueous phase was extracted with CH₂ Cl₂ (3*50 mL). The combined CH₂ Cl₂ extracts were washed with sat. NaCl solution, dried with anhydrous MgSO₄, are concentrated under reduced pressure. Silica gel chromatc,graphy (CH₂ Cl₂ /MeOH/NH₄ OH; 94:6:0.6) of the residue yielded 1-(6-chloro-2-pyridinyl)piperazine (4.80 g; 90%).