ChemicalBook CAS DataBase List 1-(5-Nitro-2-pyridinyl)-4-piperidinol

1-(5-Nitro-2-pyridinyl)-4-piperidinol synthesis

5synthesis methods

Product Name:1-(5-Nitro-2-pyridinyl)-4-piperidinol
CAS Number:353258-16-9
Molecular formula:C10H13N3O3
Molecular Weight:223.23

5382-16-1
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4548-45-2 Synthesis

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353258-16-9
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Yield:353258-16-9 97%

Reaction Conditions:

in propan-1-ol at 100; for 1.5 h;

Steps:

73

To a suspension of 1.0g (6.3mmol) of 2-chloro-5-nitropyridine in 20mL of n-propanol was added 1. 9g (18.9mmol) of 4-hydroxypiperidine, and the mixture was stirred for 1.5 hours at 100°C. After cooling the reaction mixture, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 50/1) to give 1. 37g (97%) of the title compound.

References:

EP1775298,2007,A1 Location in patent:Page/Page column 35

4548-45-2 Synthesis

4548-45-2
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5382-17-2 Synthesis