1-Acetoxy-4-diethylamino-2-butyne synthesis
- Product Name:1-Acetoxy-4-diethylamino-2-butyne
- CAS Number:22396-77-6
- Molecular formula:C10H17NO2
- Molecular Weight:183.25
10575-25-4
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$33.20/5g
108-24-7
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$14.00/250ML
64-19-7
1536 suppliers
$10.00/25ML
22396-77-6
110 suppliers
$42.20/5g
Yield:22396-77-6 81%
Reaction Conditions:
Stage #1:4-diethylamino-2-butyn-1-ol;acetic anhydride;acetic acid with sulfuric acid at 65 - 70; for 2 h;
Stage #2: with sodium hydrogencarbonate in dichloromethane;waterSaturated solution;
Steps:
2
Example-2; Preparation of diethylamino-2-butvnylacetateA mixture of 4-diethylamino-2-butyne-l-ol (30Og), acetic acid (600ml); acetic anhydride (300ml) and con.sulphuric acid (15ml) was heated to 65-70° C. After 2hrs.of maintenance excess solvent mixture was evaporated at reduced pressure. The residue was cooled and poured in a mixture of dichloromethane (1800ml) and DM water (3000ml).The reaction mass was saturated with sodium bicarbonate (300g) solid slowly controlling effervescences. The organic layer was separated and washed with 2% sodium bicarbonate and 1% EDTA solution to afford 318g (81%) of product as oil.
References:
MATRIX LABORATORIES LIMITED WO2009/122429, 2009, A2 Location in patent:Page/Page column 6
50-00-0
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627-09-8
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109-89-7
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22396-77-6
110 suppliers
$42.20/5g
79-20-9
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$14.00/100g
10575-25-4
84 suppliers
$33.20/5g
22396-77-6
110 suppliers
$42.20/5g