(1-BENZYL-2-SULFANYL-1H-IMIDAZOL-5-YL)METHANOL synthesis

5synthesis methods

Product Name:(1-BENZYL-2-SULFANYL-1H-IMIDAZOL-5-YL)METHANOL
CAS Number:98412-23-8
Molecular formula:C11H12N2OS
Molecular Weight:220.29

96-26-4 Synthesis

96-26-4
467 suppliers
$9.00/10g

333-20-0
430 suppliers
$13.50/100G

100-46-9 Synthesis

100-46-9
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$5.00/5G

(1-BENZYL-2-SULFANYL-1H-IMIDAZOL-5-YL)METHANOL

98412-23-8
26 suppliers
$45.00/50mg

Yield:98412-23-8 98%

Reaction Conditions:

with hydrogenchloride;propionic acid in water monomer;acetonitrile at 70; for 3 h;

Steps:

2.2. General Procedure for the Synthesis of Compounds10 and 11

General procedure: To a stirring solution of appropriate amines (30 mmol) inacetonitrile (30 mL), 37% HCl was added (2.5 mL, 30mmol) at 0 °C, which formed a white solid in 3 minutes.Then propionic acid (2.5 mL), dihydroxyacetone (4.5 g, 25mmol), and KSCN (2.9 g, 30 mmol) were added. The reactionmixture was refluxed at 70 °C for 3 hours. The formedprecipitate was filtered and washed with water and ethanol togive compounds 10 and 11.(1-benzyl-2-mercapto-1H-imidazol-5-yl)methanol (10).Yield 98%; 229.4 °C; IR (CCl3) υ (cm-1) 2030-3484 (O-Halcoholic), LC-MS (ESI) m/z 221.0000 (M+H+).

References:

Karimi, Nafiseh;Roudsari, Rouhollah Vahabpour;Hajimahdi, Zahra;Zarghi, Afshin [Medicinal Chemistry,2022,vol. 18,# 5,p. 616 - 628]